A substantial amount of research has shown that N-methyl-D-aspartate receptors (NMDARs)
may play a key role in the pathophysiology of several neurological diseases, including …

JUSTIFICATIVA E OBJETIVOS: A lidocaína é utilizada por via venosa desde a década de
1960 para diversas finalidades. Seu mecanismo de ação multimodal foi o objetivo principal …

Total intravenous anesthesia (TIVA) with propofol and opioids is frequently utilized for spinal
surgery where somatosensory evoked potentials (SSEP) and motor evoked potentials …

Status epilepticus (SE), a neurological emergency both in adults and in children, could lead
to brain damage and even death if untreated. Generalized convulsive SE (GCSE) is the most …

Background Spinal cord ischemia and paralysis are devastating perioperative complications
that can accompany open or endovascular repair surgery for aortic aneurysms. Here, we …

Despite the introduction of new drugs and techniques, it is recognized that many human
patients experience moderate to severe pain postoperatively. In addition, it is now …

BACKGROUND: The anesthetic effect of volatile anesthetics can be quantified by the
minimum alveolar concentration (MAC) of the drug that prevents movement in response to a …

As drug-induced seizures have severe impact on drug development, evaluating seizure
induction potential of candidate drugs at the early stages of drug discovery is important. A …

Seizures and status epilepticus are common in critically ill patients. They can be difficult to
recognize because most are nonconvulsive and require electroencephalogram monitoring …

Abstract Background Context Lidocaine has emerged as a useful adjuvant anesthetic agent
for cases requiring intraoperative monitoring of motor-evoked potentials (MEPs) and …