Adult growth hormone deficiency (GHD) is characterized by metabolic abnormalities
associated with visceral obesity, impaired quality of life, and increased mortality. Patients …

In the cytoplasm, DNA is sensed as a universal danger signal by the innate immune system.
Cyclic GMP–AMP synthase (cGAS) is a cytosolic DNA sensor/enzyme that catalyzes …

Chronic inflammation in adipose tissue plays a key role in obesity-induced insulin
resistance. However, the mechanisms underlying obesity-induced inflammation remain …

Recent studies have reported that upregulation of disulfide-bond A oxidoreductase-like
protein (DsbA-L) prevented lipid-induced renal injury in diabetic nephropathy (DN) …

Adiponectin is an adipokine that exerts insulin-sensitizing and anti-inflammatory roles in
insulin target tissues including liver. While the insulin-sensitizing function of adiponectin has …

Peroxisomes are metabolically active organelles that are known for exerting oxidative
metabolism, but the precise mechanism remains unclear in diabetic nephropathy (DN) …

Purpose: The aim of the study was to examine the effects of resveratrol upon hepatic
endoplasmic reticulum stress (ERS) and insulin sensitivity in vivo and in vitro. Material and …

Mitochondrial DNA (mtDNA) haplogroups have been associated with the incidence of type 2
diabetes (T2D); however, their underlying role in T2D remains poorly elucidated. Here, we …

Excessive mitochondrial fission has been identified as the central pathogenesis of diabetic
kidney disease (DKD), but the precise mechanisms remain unclear. Disulfide-bond A …

Renal fibrosis is the final pathological change in renal disease, and aging is closely related
to renal fibrosis. Mitochondrial dysfunction has been reported to play an important role in …