Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …

Streptococcus pneumoniae has a complex relationship with its obligate human host. On the
one hand, the pneumococci are highly adapted commensals, and their main reservoir on the …

Streptococcus pneumoniae (pneumococcus) is a major human pathogen producing
structurally diverse capsular polysaccharides. Widespread use of highly successful …

Bacteria are prime cell factories that can efficiently convert carbon and nitrogen sources into
a large diversity of intracellular and extracellular biopolymers, such as polysaccharides …

Abstract Background Pneumococcal conjugate vaccines (PCVs) have significantly reduced
pneumococcal disease, but disease from non-PCV serotypes remains. The safety …

Streptococcus pneumoniae is an infectious pathogen responsible for millions of deaths
worldwide. Diseases caused by this bacterium are classified as pneumococcal diseases …

Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

The use of vaccines have resulted in a remarkable improvement in global health. It has
saved several lives, reduced treatment costs and raised the quality of animal and human …

Background Invasive pneumococcal disease remains an important health priority owing to
increasing disease incidence caused by pneumococci expressing non-vaccine serotypes …

The ability to produce polysaccharides with diverse biological functions is widespread in
bacteria. In lactic acid bacteria (LAB), production of polysaccharides has long been …