Personalized biological treatment for rheumatoid arthritis: a systematic review with a focus on clinical applicability

BVJ Cuppen, PMJ Welsing, JJ Sprengers… - …, 2016 - academic.oup.com
Objectives. To review studies that address prediction of response to biologic treatment in RA
and to explore the clinical utility of the studied (bio) markers. Methods. A search for relevant …

T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection

EF McKinney, JC Lee, DRW Jayne, PA Lyons… - Nature, 2015 - nature.com
The clinical course of autoimmune and infectious disease varies greatly, even between
individuals with the same condition. An understanding of the molecular basis for this …

Gene expression analysis in RA: towards personalized medicine

AN Burska, K Roget, M Blits, L Soto Gomez… - The …, 2014 - nature.com
Gene expression has recently been at the forefront of advance in personalized medicine,
notably in the field of cancer and transplantation, providing a rational for a similar approach …

[HTML][HTML] Gene selection for microarray cancer classification using a new evolutionary method employing artificial intelligence concepts

M Dashtban, M Balafar - Genomics, 2017 - Elsevier
Gene selection is a demanding task for microarray data analysis. The diverse complexity of
different cancers makes this issue still challenging. In this study, a novel evolutionary …

Integration of computational docking into anti-cancer drug response prediction models

O Narykov, Y Zhu, T Brettin, YA Evrard, A Partin… - Cancers, 2023 - mdpi.com
Simple Summary Anti-cancer drug response prediction models aim to reduce the time
necessary for developing a treatment for patients affected by this complex disease. Their …

Clinical validation of a blood-based predictive test for stratification of response to tumor necrosis factor inhibitor therapies in rheumatoid arthritis patients

T Mellors, JB Withers, A Ameli, A Jones… - Network and Systems …, 2020 - liebertpub.com
Objectives: For rheumatoid arthritis (RA) patients failing to achieve treatment targets with
conventional synthetic disease-modifying antirheumatic drugs, tumor necrosis factor (TNF)-α …

A molecular signature response classifier to predict inadequate response to tumor necrosis factor-α inhibitors: the NETWORK-004 prospective observational study

S Cohen, AF Wells, JR Curtis, R Dhar, T Mellors… - Rheumatology and …, 2021 - Springer
Introduction Timely matching of patients to beneficial targeted therapy is an unmet need in
rheumatoid arthritis (RA). A molecular signature response classifier (MSRC) that predicts …

Preclinical Characterization of Pharmacologic NAD+ Boosting as a Promising Therapeutic Approach in Rheumatoid Arthritis

C Perez‐Sanchez, A Escudero‐Contreras… - Arthritis & …, 2023 - Wiley Online Library
Objective We analyzed NAD+ metabolism in patients with rheumatoid arthritis (RA), its
association with disease activity and clinical outcomes of RA, and the therapeutic potential …

CNN based 3D facial expression recognition using masking and landmark features

H Yang, L Yin - 2017 seventh international conference on …, 2017 - ieeexplore.ieee.org
Automatically recognizing facial expression is an important part for human-machine
interaction. In this paper, we first review the previous studies on both 2D and 3D facial …

Clinical utility and cost savings in predicting inadequate response to anti-TNF therapies in rheumatoid arthritis

MJ Bergman, AJ Kivitz, DA Pappas, JM Kremer… - Rheumatology and …, 2020 - Springer
Abstract Introduction The PrismRA® test identifies rheumatoid arthritis (RA) patients who are
unlikely to respond to anti-tumor necrosis factor (anti-TNF) therapies. This study evaluated …