The use of asparaginase to reduce acrylamide levels in cooked food

F Xu, MJ Oruna-Concha, JS Elmore - Food chemistry, 2016 - Elsevier
Strategies proposed for reducing the formation of the suspected carcinogen acrylamide in
cooked foods often rely on a reduction in the extent of the Maillard reaction, in which …

Acrylamide in human diet, its metabolism, toxicity, inactivation and the associated European Union legal regulations in food industry

A Koszucka, A Nowak, I Nowak… - Critical reviews in food …, 2020 - Taylor & Francis
Nowadays acrylamide is known not only as synthetic material used in industry, but also as
carcinogenic, cyto-and genotoxic compound which forms during heat-induced process (due …

Recent developments in L-asparaginase discovery and its potential as anticancer agent

A Shrivastava, AA Khan, M Khurshid, MA Kalam… - Critical reviews in …, 2016 - Elsevier
Abstract l-Asparaginase (EC3. 5.1. 1) is an enzyme, which is used for treatment of acute
lymphoblastic leukaemia (ALL) and other related blood cancers from a long time. This …

Recent Strategies and Applications for l-Asparaginase Confinement

JCF Nunes, RO Cristóvão, MG Freire… - Molecules, 2020 - mdpi.com
l-asparaginase (ASNase, EC 3.5. 1.1) is an aminohydrolase enzyme with important uses in
the therapeutic/pharmaceutical and food industries. Its main applications are as an …

A comprehensive review on microbial l‐asparaginase: Bioprocessing, characterization, and industrial applications

S Chand, RV Mahajan, JP Prasad… - Biotechnology and …, 2020 - Wiley Online Library
Abstract l‐Asparaginase (EC 3.5. 1.1.) is a vital enzyme that hydrolyzes l‐asparagine to l‐
aspartic acid and ammonia. This property of l‐asparaginase inhibits the protein synthesis in …

Therapeutic l-asparaginase: upstream, downstream and beyond

AM Lopes, L Oliveira-Nascimento… - Critical reviews in …, 2017 - Taylor & Francis
Abstract l-asparaginase (l-asparagine amino hydrolase, EC 3.5. 1.1) is an enzyme clinically
accepted as an antitumor agent to treat acute lymphoblastic leukemia and lymphosarcoma …

Production and Anticancer Activity of an L-Asparaginase from Bacillus licheniformis Isolated from the Red Sea, Saudi Arabia

SA Alrumman, YS Mostafa, KA Al-Izran, MY Alfaifi… - Scientific reports, 2019 - nature.com
Microbial L-asparaginase (ASNase) is an important anticancer agent that is used
extensively worldwide. In this study, 40 bacterial isolates were obtained from the Red Sea of …

Production of a Novel Marine Pseudomonas aeruginosa Recombinant L-Asparaginase: Insight on the Structure and Biochemical Characterization

F Izadpanah Qeshmi, A Homaei, K Khajeh… - Marine …, 2022 - Springer
The present study focused on the cloning, expression, and characterization of L-
asparaginase of marine Pseudomonas aeruginosa HR03 isolated from fish intestine. Thus …

Acrylamide: inhibition of formation in processed food and mitigation of toxicity in cells, animals, and humans

M Friedman - Food & function, 2015 - pubs.rsc.org
Potentially toxic acrylamide is largely derived from the heat-inducing reactions between the
amino group of the amino acid asparagine and carbonyl groups of glucose and fructose in …

Microbial enzymes for deprivation of amino acid metabolism in malignant cells: biological strategy for cancer treatment

R Dhankhar, V Gupta, S Kumar, RK Kapoor… - Applied Microbiology and …, 2020 - Springer
Amino acid deprivation therapy (AADT) is emerging as a promising strategy for the
development of novel therapeutics against cancer. This biological therapy relies upon the …