Plasma utilization has increased over the past two decades, and there is a growing concern
that many plasma transfusions are inappropriate. Plasma transfusion is not without risk, and …

Enzymes catalyze biochemical reactions and play critical roles in human health and
disease. Enzyme variants and deficiencies can lead to variable expression of glycans, which …

The premier single-volume reference in the field of anesthesia, Clinical Anesthesia is now in
its Sixth Edition, with thoroughly updated coverage, a new full-color design, and a revamped …

Background The increasing use of fresh blood group O whole blood in acute trauma
medicine makes it important to reevaluate the issue of hemolytic reactions related to the …

Platelets express ABO antigens and are collected in plasma, which contains ABO antibodies
as would be consistent with the donor ABO group. Platelet ABO antigens that are …

Clinically significant hemolysis is a rare but potentially severe complication of administering
an ABO-mismatched platelet transfusion. Platelet products from Group O donors, particularly …

Patients with hypoproliferative thrombocytopenia are at an increased risk for hemorrhage
and alloimmunization to platelets. Updated guidance for optimizing platelet transfusion …

BACKGROUND: The overall risk of hemolytic transfusion reactions (HTRs) from plasma
(minor)‐incompatible platelet (PLT) transfusions and the role of a critical anti‐A or anti‐B titer …

Platelet transfusions play a central role in therapeutic regimens for patients with
hematologic/oncologic diseases who develop severe thrombocytopenia either in the course …

Glycosylation is highly prevalent, and also one of the most complex and varied
posttranslational modifications. This large glycan diversity results in a wide range of …