Tissue Treg secretomes and transcription factors shared with stem cells contribute to a Treg niche to maintain Treg-ness with 80% innate immune pathways, and …

R Zhang, K Xu, Y Shao, Y Sun, J Saredy… - Frontiers in …, 2021 - frontiersin.org
We used functional-omics angles and examined transcriptomic heterogeneity in CD4+
Foxp3+ regulatory T cells (Treg) from spleen (s-Treg), lymph nodes (LN-Treg), intestine (int …

[HTML][HTML] Increased acetylation of H3K14 in the genomic regions that encode trained immunity enzymes in lysophosphatidylcholine-activated human aortic endothelial …

Y Lu, Y Sun, C Drummer IV, GK Nanayakkara, Y Shao… - Redox biology, 2019 - Elsevier
To test our hypothesis that proatherogenic lysophosphatidylcholine (LPC) upregulates
trained immunity pathways (TIPs) in human aortic endothelial cells (HAECs), we conducted …

Increasing Upstream Chromatin Long–Range Interactions May Favor Induction of Circular RNAs in LysoPC-Activated Human Aortic Endothelial Cells

A Li, Y Sun, C Drummer IV, Y Lu, D Yu, Y Zhou… - Frontiers in …, 2019 - frontiersin.org
Circular RNAs (circRNAs) are non-coding RNAs that form covalently closed continuous
loops, and act as gene regulators in physiological and disease conditions. To test our …