Mechanical forces associated with blood flow play important roles in the acute control of
vascular tone, the regulation of arterial structure and remodeling, and the localization of …

Atherosclerotic plaques are found at distinct locations in the arterial system, despite the
exposure to systemic risk factors of the entire vascular tree. From the study of arterial …

Fluid velocities were measured by laser Doppler velocimetry under conditions of pulsatile
flow in a scale model of the human carotid bifurcation. Flow velocity and wall shear stress at …

Atherosclerosis affects the major elastic and muscular arteries, but some vessels are largely
spared while others may be markedly diseased. The carotid bifurcation, the coronary …

A three-dimensional finite element model of the carotid artery bifurcation was constructed in
order to determine the stress field and assess the modification of the stress field when …

Oscillatory shear stress occurs at sites of the circulation that are vulnerable to
atherosclerosis. Because oxidative stress contributes to atherosclerosis, we sought to …

It is well accepted that atherosclerosis occurs in a site-specific manner especially at branch
points where disturbed blood flow (d-flow) predisposes to the development of plaques …

Numerical analysis of flow phenomena and wall shear stresses in the human carotid artery
bifurcation has been carried out using a three-dimensional geometrical model. The primary …

Vascular smooth muscle cells (VSMC) exhibit several growth responses to agonists that
regulate their function including proliferation (hyperplasia with an increase in cell number) …

The role of heart rate in the development of coronary atherosclerosis was assessed in adult
male cynomolgus monkeys (Macaca fascicularis). Heart rate was lowered in six animals by …