Classical and noncanonical functions of miRNAs in cancers

MP Dragomir, E Knutsen, GA Calin - Trends in Genetics, 2022 - cell.com
Alterations in microRNAs (miRNAs) expression are causative in the initiation and
progression of human cancers. The molecular events responsible for the widespread …

Systems and synthetic microRNA biology: from biogenesis to disease pathogenesis

H Matsuyama, HI Suzuki - International journal of molecular sciences, 2019 - mdpi.com
MicroRNAs (miRNAs) are approximately 22-nucleotide-long, small non-coding RNAs that
post-transcriptionally regulate gene expression. The biogenesis of miRNAs involves multiple …

Regulatory mechanisms of epigenetic miRNA relationships in human cancer and potential as therapeutic targets

KMT Arif, EK Elliott, LM Haupt, LR Griffiths - Cancers, 2020 - mdpi.com
Simple Summary By the virtue of targeting multiple genes, a microRNA (miRNA) can infer
variable consequences on tumorigenesis by appearing as both a tumour suppressor and …

DNA methylation directs microRNA biogenesis in mammalian cells

O Glaich, S Parikh, RE Bell, K Mekahel… - Nature …, 2019 - nature.com
MicroRNA (miRNA) biogenesis initiates co-transcriptionally, but how the Microprocessor
machinery pinpoints the locations of short precursor miRNA sequences within long flanking …

Physical activity and DNA methylation in humans

WJ Światowy, H Drzewiecka, M Kliber… - International journal of …, 2021 - mdpi.com
Physical activity is a strong stimulus influencing the overall physiology of the human body.
Exercises lead to biochemical changes in various tissues and exert an impact on gene …

Mechanistic actions of microRNAs in diabetic wound healing

M Petkovic, AE Sørensen, EC Leal, E Carvalho… - Cells, 2020 - mdpi.com
Wound healing is a complex biological process that is impaired under diabetes conditions.
Chronic non-healing wounds in diabetes are some of the most expensive healthcare …

Crosstalk between miRNAs and DNA Methylation in Cancer

M Saviana, P Le, L Micalo, D Del Valle-Morales… - Genes, 2023 - mdpi.com
miRNAs are some of the most well-characterized regulators of gene expression. Integral to
several physiological processes, their aberrant expression often drives the pathogenesis of …

Developmental origins of type 2 diabetes: Focus on epigenetics

A Vaiserman, O Lushchak - Ageing Research Reviews, 2019 - Elsevier
Traditionally, genetics and lifestyle are considered as main determinants of aging-
associated pathological conditions. Accumulating evidence, however, suggests that risk of …

Histone methylation-mediated microRNA-32-5p down-regulation in sensory neurons regulates pain behaviors via targeting Cav3. 2 channels

R Qi, J Cao, Y Sun, Y Li, Z Huang… - Proceedings of the …, 2022 - National Acad Sciences
microRNA (miRNA)–mediated gene regulation has been studied as a therapeutic approach,
but its functional regulatory mechanism in neuropathic pain is not well understood. Here, we …

The epigenetic modulation of cancer and immune pathways in hepatitis B virus-associated hepatocellular carcinoma: the influence of HBx and miRNA dysregulation

K Sartorius, P An, C Winkler, A Chuturgoon… - Frontiers in …, 2021 - frontiersin.org
Hepatitis B virus (HBV)-associated hepatocellular carcinoma (HBV-HCC) pathogenesis is
fueled by persistent HBV infection that stealthily maintains a delicate balance between viral …