Mitochondria form a highly interconnected tubular network throughout the cell via a dynamic
process, with mitochondrial segments fusing and breaking apart continuously. Strong …

Recent advances in mitochondrial biology have revealed the high diversity and complexity
of proteolytic enzymes that regulate mitochondrial function. We have classified mitochondrial …

The BCL2 family plays important roles in acute myeloid leukemia (AML). Venetoclax, a
selective BCL2 inhibitor, has received FDA approval for the treatment of AML. However …

Mitochondria are essential metabolic hubs that dynamically adapt to physiological demands.
More than 40 proteases residing in different compartments of mitochondria, termed …

Recent years have seen renewed interest in the permeability transition pore, a high
conductance channel responsible for permeabilization of the inner mitochondrial …

Mutations in subunits of mitochondrial m-AAA proteases in the inner membrane cause
neurodegeneration in spinocerebellar ataxia (SCA28) and hereditary spastic paraplegia …

Adaptive stress responses activated upon mitochondrial dysfunction are assumed to arise in
order to counteract respiratory chain deficiency. Here, we demonstrate that loss of DARS2 …

There is currently no accepted classification of autosomal recessive cerebellar ataxias, a
group of disorders characterized by important genetic heterogeneity and complex …

Mitochondria adapt to different energetic demands reshaping their proteome. Mitochondrial
proteases are emerging as key regulators of these adaptive processes. Here, we use a …

Prohibitins form large protein and lipid scaffolds in the inner membrane of mitochondria that
are required for mitochondrial morphogenesis, neuronal survival, and normal lifespan. Here …