Molecular mechanisms of cutaneous squamous cell carcinoma

ML Hedberg, CT Berry, AS Moshiri, Y Xiang… - International Journal of …, 2022 - mdpi.com
Non-melanoma skin cancers are cutaneous malignancies representing the most common
form of cancer in the United States. They are comprised predominantly of basal cell …

Ultraviolet radiation and skin cancer: molecular mechanisms

MR Hussein - Journal of cutaneous pathology, 2005 - Wiley Online Library
Every living organism on the surface of the earth is exposed to the ultraviolet (UV) fraction of
the sunlight. This electromagnetic energy has both life‐giving and life‐endangering effects …

Photocarcinogenesis and skin cancer prevention strategies: an update

MC Martens, C Seebode, J Lehmann… - Anticancer …, 2018 - ar.iiarjournals.org
UV radiation is acknowledged as the primary cause of photocarcinogenesis and therefore
contributes to the development of skin cancer entities such as squamous cell carcinoma …

[HTML][HTML] p16INK4a and p14ARF tumor suppressor genes are commonly inactivated in cutaneous squamous cell carcinoma

VL Brown, CA Harwood, T Crook, JG Cronin… - Journal of investigative …, 2004 - Elsevier
The p16 INK4a and p14 ARF tumor suppressor genes (TSGs) are encoded within the
CDKN2A locus on chromosome 9p21 and function as cell cycle regulatory proteins in the …

Human papillomaviruses and non‐melanoma skin cancer: basic virology and clinical manifestations

I Nindl, M Gottschling, E Stockfleth - Disease markers, 2007 - Wiley Online Library
Human papillomaviruses (HPV) infect cutaneous and mucosal epithelia and induce benign
and malignant lesions. Non‐melanoma skin cancer (NMSC), encompassing basal cell …

The Role of p16INK4a Pathway in Human Epidermal Stem Cell Self-Renewal, Aging and Cancer

D D'Arcangelo, L Tinaburri, E Dellambra - International journal of …, 2017 - mdpi.com
The epidermis is a self-renewing tissue. The balance between proliferation and
differentiation processes is tightly regulated to ensure the maintenance of the stem cell (SC) …

BRAF mutations, microsatellite instability status and cyclin D1 expression predict metastatic colorectal patients' outcome

Z Saridaki, D Papadatos-Pastos, M Tzardi… - British journal of …, 2010 - nature.com
Background: The significance of BRAF mutations, microsatelite instability (MSI) status and
cyclin D1 expression in patients with metastatic colorectal cancer (mCRC) was evaluated …

Significant involvement of CCR2–64I and CXCL12–3a in the development of sporadic breast cancer

A Zafiropoulos, N Crikas, AM Passam… - Journal of medical …, 2004 - jmg.bmj.com
MATERIALS AND METHODS Patients and samples Breast cancer Blood samples were
collected at the Prolepsis (centre for breast cancer diagnosis and research in Athens …

Genomic instability, mutations and expression analysis of the tumour suppressor genes p14ARF, p15INK4b, p16INK4a and p53 in actinic keratosis

P Kanellou, A Zaravinos, M Zioga, A Stratigos… - Cancer letters, 2008 - Elsevier
Actinic keratosis (AK) is a well-established pre-cancerous skin lesion that has the potential
to progress to squamous cell carcinoma (SCC). We investigated the involvement of the …

Keratinocytic skin cancers—Update on the molecular biology

TS Win, H Tsao - Cancer, 2023 - Wiley Online Library
Although much attention has been devoted to a detailed genomic exposition of cutaneous
melanoma, other nonmelanoma skin cancers have also recently been subjected to similar …