Cardiovascular diseases are the leading cause of death worldwide. Overweight and obesity
are strongly associated with comorbidities such as hypertension and insulin resistance …

Brown and beige adipocytes are mitochondria-enriched cells capable of dissipating energy
in the form of heat. These thermogenic fat cells were originally considered to function solely …

Multipotent stromal cells (MSCs) are vital for development, maintenance, function, and
regeneration of most tissues. They can differentiate along multiple connective lineages, but …

Two types of thermogenic fat cells, brown adipocytes and beige adipocytes, play a key role
in the regulation of systemic energy homeostasis in mammals. Both brown fat and beige fat …

The recent epidemics of metabolic diseases, obesity, type 2 diabetes (T2D), liver lipid
disorders and metabolic syndrome have largely been attributed to genetic background and …

Skeletal muscle is the largest tissue in the body and loss of its function or its regenerative
properties results in debilitating musculoskeletal disorders. Understanding the mechanisms …

Brown and beige adipocytes expend chemical energy to produce heat and are therefore
important in regulating body temperature and body weight. Brown adipocytes develop in …

Since brown adipose tissue (BAT) dissipates energy through UCP1, BAT has garnered
attention as a therapeutic intervention for obesity and metabolic diseases including type 2 …

INTRODUCTION Fibroblasts are the predominant cell type that synthesizes and remodels
the extracellular matrix in organs during both embryonic and adult life and are central to the …

White adipose tissue (WAT) has key metabolic and endocrine functions and plays a role in
regulating energy homeostasis and insulin sensitivity. WAT is characterised by its capacity to …