Background Overviews of systematic reviews are an increasingly popular method of
evidence synthesis; there is a lack of clear guidance for completing overviews and a number …

The past five decades have seen an improvement in the mortality and morbidity of sickle cell
disease (SCD) because of prophylaxis against infectious complications, improved and …

Sickle Cell Pain is a panoramic, in-depth exploration of every scientific, human, and social
dimension of this cruel disease. This comprehensive, definitive work is unique in that it is the …

Significance: Sickle-cell leg ulcers (SCLUs) are a severe, chronic, and recurrent
complication of sickle-cell disease (SCD). There are no official recommendations for …

Background Sickle cell disease (SCD) impacts millions of individuals worldwide and more
than 100,000 people in the United States. Leg ulcers are the most common cutaneous …

Leg ulcers are a debilitating complication of patients with sickle cell disease, and their
frequency in North America was reported to be 2.5% by the Cooperative Study of Sickle Cell …

Background Globally, sickle cell disease (SCD) is one of the commonest severe monogenic
disorders, due to the inheritance of two abnormal haemoglobin (beta globin) genes. SCD …

2. Rummel MJ, Niederle N, Maschmeyer G, et al. Bendamustine plus rituximab versus
CHOP plus rituximab as first-line treatment for patients with indolent and mantle-cell …

Sickle cell disease (SCD) affects approximately 100 000 people in the US, 12 500 in the UK,
and millions worldwide. SCD is typified by painful vaso‐occlusive episodes, haemolytic …

Background Sickle cell disease (SCD) includes a group of inherited haemoglobinopathies
affecting multiple organs including the eyes. Some people with SCD develop ocular …