Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central
nervous system afflicting nearly three million individuals worldwide. Neuroimmune …

Glial cells are abundant in the CNS and are essential for brain development and
homeostasis. These cells also regulate tissue recovery after injury and their dysfunction is a …

Microglia are implicated in all stages of multiple sclerosis (MS). Microglia alterations are
detected by positron emission tomography in people living with MS prior to the formation of …

Despite the large number of immunomodulatory or immunosuppressive treatments available
to treat relapsing–remitting multiple sclerosis (MS), treatment of the progressive phase of the …

The emerging roles of microglia are currently being investigated in the healthy and diseased
brain with a growing interest in their diverse functions. In recent years, it has been …

Multiple sclerosis is characterized by inflammatory activity that results in destruction of the
myelin sheaths that enwrap axons. The currently available medications for multiple sclerosis …

Remyelination failure contributes to axonal loss and progression of disability in multiple
sclerosis. The failed repair process could be due to ongoing toxic neuroinflammation and to …

Abstract The Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT)
signaling pathway is utilized by numerous cytokines and interferons, and is essential for the …

Regional differences in neurons, astrocytes, oligodendrocytes, and microglia exist in the
brain during health, and regional differences in the transcriptome may occur for each cell …

Remyelination failure in multiple sclerosis (MS) contributes to progression of disability. The
deficient repair results from neuroinflammation and deposition of inhibitors including …