Fentanyl is a synthetic, highly selective opioid with many desirable physicochemical
properties, including a high lipophilicity and predictable pharmacokinetics. These properties …

This paper is the thirty-fifth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2012 …

Although the majority of potentially preventable fatalities among US combat forces serving in
Afghanistan and Iraq have died from hemorrhagic shock, the majority of US medics carry …

We report the results of a process improvement initiative to examine the current use and
safety of prehospital pain medications by US Forces in Afghanistan. Prehospital pain …

Abstract Background: Tactical Combat Casualty Care (TCCC) guidelines regarding
prehospital analgesia agents have evolved. The guidelines stopped recommending …

The development and advancement of trauma care has shown stepwise improvements for
centuries owing to the interrelationship of civilian and military medical systems. With respect …

Introduction We examine the current status of the military relevance of opioids, their use and
misuse in military and veteran populations, the national security consequences of opioid use …

Background: Combat injuries result in acute, severe pain. Early use of analgesia after injury
is known to be beneficial. Studies on prehospital analgesia in combat are limited and no …

BACKGROUND Opioid-induced respiratory depression (OIRD) and postoperative apnea
(POA) can lead to complications after surgery or traumatic injury. Previously, real-time …

Background: Published data on prehospital medical care in combat is limited, likely due to
the chaotic and unpredictable nature of care under fire and difficulty in documentation There …