Telomeres are dynamic nucleoprotein-DNA structures that cap and protect linear
chromosome ends. Because telomeres shorten progressively with each replication, they …

Germline aberrations in critical DNA-repair and DNA damage–response (DDR) genes
cause cancer predisposition, whereas various tumors harbor somatic mutations causing …

The potential of the cluster regularly interspaced short palindromic repeat (CRISPR)‐
associated protein 9 (Cas9)‐based therapeutic genome editing is severely hampered by the …

Genome instability is a hallmark of cancer, and DNA replication is the most vulnerable
cellular process that can lead to it. Any condition leading to high levels of DNA damage will …

Abstract Human MutT Homolog 1 (MTH1) is a nucleotide pool sanitization enzyme that
hydrolyzes oxidized nucleotides to prevent their mis-incorporation into DNA under oxidative …

Thermal proteome profiling (TPP) is based on the principle that, when subjected to heat,
proteins denature and become insoluble. Proteins can change their thermal stability upon …

Three processes act in series to accurately replicate the eukaryotic nuclear genome. The
major replicative DNA polymerases strongly prevent mismatch formation, occasional …

Cancers remain a major public health problem worldwide, which still require profound
research in both the basic and preclinical fields. Patient-derived xenograft (PDX) models are …

Loss of LKB1 is associated with increased metastasis and poor prognosis in lung cancer,
but the development of targeted agents is in its infancy. Here we report that a glutaminolytic …

The pET series of expression plasmids are widely used for recombinant protein production
in Escherichia coli. The genetic modules controlling transcription and translation in these …