Emerging role of vitamin D in autoimmune diseases: An update on evidence and therapeutic implications

G Murdaca, A Tonacci, S Negrini, M Greco, M Borro… - Autoimmunity …, 2019 - Elsevier
Vitamin D plays a key role in in calcium homeostasis and, thus, provides an important
support in bone growth by aiding in the mineralization of the collagen matrix. However …

Influence of vitamin D on islet autoimmunity and beta-cell function in type 1 diabetes

M Infante, C Ricordi, J Sanchez, MJ Clare-Salzler… - Nutrients, 2019 - mdpi.com
Type 1 diabetes (T1D) is a chronic autoimmune disease leading to immune-mediated
destruction of pancreatic beta cells, resulting in the need for insulin therapy. The incidence …

Vitamin D levels and risk of type 1 diabetes: A Mendelian randomization study

D Manousaki, A Harroud, RE Mitchell, S Ross… - PLoS …, 2021 - journals.plos.org
Background Vitamin D deficiency has been associated with type 1 diabetes in observational
studies, but evidence from randomized controlled trials (RCTs) is lacking. The aim of this …

DHCR7: A vital enzyme switch between cholesterol and vitamin D production

AV Prabhu, W Luu, D Li, LJ Sharpe, AJ Brown - Progress in lipid research, 2016 - Elsevier
The conversion of 7-dehydrocholesterol to cholesterol, the final step of cholesterol synthesis
in the Kandutsch-Russell pathway, is catalyzed by the enzyme 7-dehydrocholesterol …

Progress in the relationship between vitamin D deficiency and the incidence of type 1 diabetes mellitus in children

LP He, YX Song, T Zhu, W Gu… - Journal of Diabetes …, 2022 - Wiley Online Library
Type 1 diabetes mellitus (T1DM) is an autoimmune disease, due to a large number of islet β
cells damaged, resulting in an absolute lack of insulin, ultimately relying on insulin therapy …

Immunomodulatory effect of vitamin D and its potential role in the prevention and treatment of type 1 diabetes mellitus—A narrative review

K Rak, M Bronkowska - Molecules, 2018 - mdpi.com
Type 1 diabetes mellitus is a chronic autoimmune disease associated with degeneration of
pancreatic β-cells that results in an inability to produce insulin and the need for exogenous …

Vitamin D and diabetes mellitus: Causal or casual association?

M Grammatiki, E Rapti, S Karras, RA Ajjan… - Reviews in Endocrine …, 2017 - Springer
The incidence of both type 2 and type 1 diabetes mellitus has been increasing worldwide.
Vitamin D deficiency, or the awareness of its prevalence, has also been increasing. Vitamin …

Seasonal variation in month of diagnosis in children with type 1 diabetes registered in 23 European centers during 1989–2008: little short‐term influence of sunshine …

CC Patterson, E Gyürüs, J Rosenbauer… - Pediatric …, 2015 - Wiley Online Library
Background The month of diagnosis in childhood type 1 diabetes shows seasonal variation.
Objective We describe the pattern and investigate if year‐to‐year irregularities are …

The role of vitamin D in the pathogenesis and treatment of diabetes mellitus: a narrative review

M Grammatiki, S Karras, K Kotsa - Hormones, 2019 - Springer
Diabetes mellitus, a metabolic disorder associated with chronic complications, is traditionally
classified into two main subtypes. Type 1 diabetes mellitus (T1DM) results from gradual …

Allogenic adipose tissue-derived stromal/stem cells and vitamin D supplementation in patients with recent-onset type 1 diabetes mellitus: a 3-month follow-up pilot …

DB Araujo, JR Dantas, KR Silva, DL Souto… - Frontiers in …, 2020 - frontiersin.org
Objective: To evaluate the short term safety and potential therapeutic effect of allogenic
adipose tissue-derived stromal/stem cells (ASCs)+ cholecalciferol in patients with recent …