Xpert® MTB/RIF assay for extrapulmonary tuberculosis and rifampicin resistance

M Kohli, I Schiller, N Dendukuri… - Cochrane Database …, 2018 - cochranelibrary.com
Background Tuberculosis (TB) is the world's leading infectious cause of death.
Extrapulmonary TB accounts for 15% of TB cases, but the proportion is increasing, and over …

A systematic review of biomarkers to detect active tuberculosis

E MacLean, T Broger, S Yerlikaya… - Nature …, 2019 - nature.com
Millions of cases of tuberculosis (TB) go undiagnosed each year. Better diagnostic tools are
urgently needed. Biomarker-based or multiple marker biosignature-based tests, ideally …

Effect on mortality of point-of-care, urine-based lipoarabinomannan testing to guide tuberculosis treatment initiation in HIV-positive hospital inpatients: a pragmatic …

JG Peter, LS Zijenah, D Chanda, P Clowes, M Lesosky… - The Lancet, 2016 - thelancet.com
Background HIV-associated tuberculosis is difficult to diagnose and results in high mortality.
Frequent extra-pulmonary presentation, inability to obtain sputum, and paucibacillary …

[HTML][HTML] Tuberculous pleural effusions: advances and controversies

MJ Vorster, BW Allwood, AH Diacon… - Journal of thoracic …, 2015 - ncbi.nlm.nih.gov
On a global scale, tuberculosis (TB) remains one of the most frequent causes of pleural
effusions. Our understanding of the pathogenesis of the disease has evolved and what was …

Xpert MTB/RIF Ultra and Xpert MTB/RIF assays for extrapulmonary tuberculosis and rifampicin resistance in adults

M Kohli, I Schiller, N Dendukuri, M Yao… - Cochrane Database …, 2021 - cochranelibrary.com
Background Xpert MTB/RIF Ultra (Xpert Ultra) and Xpert MTB/RIF are World Health
Organization (WHO)‐recommended rapid nucleic acid amplification tests (NAATs) widely …

Tuberculous pleural effusion

JA Shaw, AH Diacon, CFN Koegelenberg - Respirology, 2019 - Wiley Online Library
Tuberculous effusion is a common disease entity with a spectrum of presentations from a
largely benign effusion, which resolves completely, to a complicated effusion with …

[HTML][HTML] Point of care diagnostics for tuberculosis

AL García-Basteiro, A DiNardo, B Saavedra, DR Silva… - Pulmonology, 2018 - Elsevier
The goals of the End TB strategy, which aims to achieve a 90% reduction in tuberculosis
(TB) incidence and a 95% reduction in TB mortality by 2035, will not be achieved without …

Determinants of PCR performance (Xpert MTB/RIF), including bacterial load and inhibition, for TB diagnosis using specimens from different body compartments

G Theron, J Peter, G Calligaro, R Meldau… - Scientific reports, 2014 - nature.com
The determinants of Xpert MTB/RIF sensitivity, a widely used PCR test for the diagnosis of
tuberculosis (TB) are poorly understood. We compared culture time-to-positivity (TTP; a …

Diagnostic performance of Xpert MTB/RIF in tuberculous pleural effusion: systematic review and meta-analysis

IS Sehgal, S Dhooria, AN Aggarwal… - Journal of clinical …, 2016 - Am Soc Microbiol
ABSTRACT A systematic review investigating the role of Xpert MTB/RIF in the diagnosis of
tuberculous pleural effusion (TPE) was conducted. The pooled sensitivities and specificities …

Tuberculous pleural effusion: diagnosis & management

L Antonangelo, CS Faria, RK Sales - Expert review of respiratory …, 2019 - Taylor & Francis
Background: Tuberculosis (TB) is the world's leading cause of death from infectious disease.
The World Health Organization (WHO) recognized 6.3 million new TB cases in 2017, 16 …