[HTML][HTML] Toxicology and pharmacology of synthetic organoselenium compounds: An update

CW Nogueira, NV Barbosa, JBT Rocha - Archives of Toxicology, 2021 - Springer
Here, we addressed the pharmacology and toxicology of synthetic organoselenium
compounds and some naturally occurring organoselenium amino acids. The use of …

Synthetic approaches and pharmaceutical applications of chloro-containing molecules for drug discovery: A critical review

WY Fang, L Ravindar, KP Rakesh… - European Journal of …, 2019 - Elsevier
At present more than 250 FDA approved chlorine containing drugs were available in the
market and many pharmaceutically important drug candidates in pre-clinical trials. Thus, it is …

[HTML][HTML] Ebselen and analogues: Pharmacological properties and synthetic strategies for their preparation

C Santi, C Scimmi, L Sancineto - Molecules, 2021 - mdpi.com
Ebselen is the leader of selenorganic compounds, and starting from its identification as
mimetic of the key antioxidant enzyme glutathione peroxidase, several papers have …

8-Hydroxyquinolines in medicinal chemistry: A structural perspective

V Oliveri, G Vecchio - European journal of medicinal chemistry, 2016 - Elsevier
Hydroxyquinolines are heterocyclic compounds characterized by a moderate metal-binding
affinity. The interest in 8-hydroxyquinolines has grown exponentially in the last two decades …

Exploring coordination preferences and biological applications of pyridyl-based organochalcogen (Se, Te) ligands

A Singh, A Kaushik, JS Dhau, R Kumar - Coordination Chemistry Reviews, 2022 - Elsevier
This review summarizes advancement in the field of pyridyl-based organochalcogen ligands
in terms of their coordination behavior and biological applications. Pyridylchalcogen …

Multi-target directed drugs as a modern approach for drug design towards Alzheimer's disease: an update

M de Freitas Silva, KST Dias, VS Gontijo… - Current Medicinal …, 2018 - ingentaconnect.com
Alzheimer's disease (AD) is a progressive multifactorial neurodegenerative disorder.
Currently, no effective treatment is available and this is due to multiple factors involved in …

[HTML][HTML] Merged tacrine-based, multitarget-directed acetylcholinesterase inhibitors 2015–present: Synthesis and biological activity

TJ Eckroat, DL Manross, SC Cowan - International journal of molecular …, 2020 - mdpi.com
Acetylcholinesterase is an important biochemical enzyme in that it controls acetylcholine-
mediated neuronal transmission in the central nervous system, contains a unique structure …

Neuropharmacology of organoselenium compounds in mental disorders and degenerative diseases

PT Birmann, AM Casaril, L Abenante… - Current Medicinal …, 2023 - ingentaconnect.com
Neurodegenerative and mental disorders are a public health burden with pharmacological
treatments of limited efficacy. Organoselenium compounds are receiving great attention in …

[HTML][HTML] Effects of linkers and substitutions on multitarget directed ligands for Alzheimer's diseases: Emerging paradigms and strategies

N Pravin, K Jozwiak - International journal of molecular sciences, 2022 - mdpi.com
Alzheimer's disease (AD) is multifactorial, progressive and the most predominant cause of
cognitive impairment and dementia worldwide. The current “one-drug, one-target” approach …

The role of green solvents and catalysts at the future of drug design and of synthesis

N Menges - Green Chem, 2017 - books.google.com
Green chemistry is getting extended in many researches and industry areas. Not only
pharmaceutical companies but also the other chemical industries started to take a step for …