Double-stranded RNA (dsRNA) is associated with most viral infections—it either constitutes
the viral genome (in the case of dsRNA viruses) or is generated in host cells during viral …

Apoptosis is associated with virus-induced human diseases of the central nervous system,
heart and liver, and causes substantial morbidity and mortality. Although virus-induced …

Intestinal epithelial cells (IECs) are constantly exposed to commensal flora and pathogen
challenges. How IECs regulate their innate immune response to maintain gut homeostasis …

The mammalian reoviruses and rotaviruses have evolved specific mechanisms to evade the
Type I interferon (IFN) antiviral response. Rotavirus likely represses the IFN response by at …

Mammalian orthoreovirus (reovirus) is a double-stranded RNA (dsRNA) virus which
encapsidates its 10 genome segments within a double-layered viral particle. Reovirus …

Mammalian orthoreovirus (reovirus) is a dsRNA virus, which has long been used as a model
system to study host–virus interactions. One of the earliest interactions during virus infection …

By using a cultured neuroblastoma cell line, the present authors recently showed that the N
protein of virulent rabies virus fixed strain Nishigahara (Ni), but not that of the attenuated …

Reovirus infection is a well-characterized experimental system for the study of viral
pathogenesis and antiviral immunity within the central nervous system (CNS). We have …

In vivo and ex vivo models of reoviral encephalitis were utilized to delineate the contribution
of type I interferon (IFN) to the host's defense against local central nervous system (CNS) …

Engagement of cell surface receptors by viruses is a critical determinant of viral tropism and
disease. The reovirus attachment protein σ1 binds sialylated glycans and proteinaceous …