Naltrexone is a semi-synthetic opioid with competitive antagonist activity at mu opioid
receptors. Its efficacy has been demonstrated in the treatment of alcohol and opioid …

Pharmacogenetic research has the potential to explain the variation in treatment efficacy
within patient populations. Understanding the interaction between genetic variation and …

Close social bonds are critical to a happy and fulfilled life and yet little is known, in humans,
about the neurochemical mechanisms that keep individuals feeling close and connected to …

Importance Alcohol use disorder is one of the leading causes of disability worldwide. While
effective pharmacological treatments exist, they are efficacious only in certain individuals …

Randomized clinical trials have established the efficacy of naltrexone for reducing quantity
of alcohol consumption and incidence of relapse to heavy drinking. To evaluate putative …

This paper is the thirty-fifth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2012 …

Naltrexone (NTX) has been widely studied for the treatment of alcohol use disorder with
overall support for its efficacy. The mechanisms of action of naltrexone are thought to involve …

Variation at a single nucleotide polymorphism in the μ-opioid receptor gene (OPRM1),
A118G (Asn40Asp), may moderate naltrexone (NTX) effects in alcohol dependence. Both …

Abstract Development of effective treatments for alcohol use disorder (AUD) represents an
important public health goal. This review provides a summary of completed preclinical and …

Abstract “Heartwarming” social experiences, when one feels interpersonally connected to
others, have recently been linked with physical warmth. According to one theory (Panksepp …