Novel therapeutic approaches for Alzheimer's disease: an updated review

TW Yu, HY Lane, CH Lin - International journal of molecular sciences, 2021 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease and accounts for
most cases of dementia. The prevalence of AD has increased in the current rapidly aging …

Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease

H Zhang, Y Wang, Y Wang, X Li, S Wang… - European Journal of …, 2022 - Elsevier
Abstract Alzheimer's disease (AD), as the fourth leading cause of death among the elderly
worldwide, has brought enormous challenge to the society. Due to its extremely complex …

Artificial intelligence and machine learning approaches using gene expression and variant data for personalized medicine

S Vadapalli, H Abdelhalim, S Zeeshan… - Briefings in …, 2022 - academic.oup.com
Precision medicine uses genetic, environmental and lifestyle factors to more accurately
diagnose and treat disease in specific groups of patients, and it is considered one of the …

[HTML][HTML] Effects of ketogenic diet on neuroinflammation in neurodegenerative diseases

Z Jiang, X Yin, M Wang, T Chen, Y Wang, Z Gao… - Aging and …, 2022 - ncbi.nlm.nih.gov
The ketogenic diet (KD) is a low-carbohydrate, high-fat and adequate-protein diet. As a diet
mimicking fasting, it triggers the production of ketone bodies (KBs) and brings the body into …

Antioxidant therapy in oxidative stress-induced neurodegenerative diseases: Role of nanoparticle-based drug delivery systems in clinical translation

A Ashok, SS Andrabi, S Mansoor, Y Kuang, BK Kwon… - Antioxidants, 2022 - mdpi.com
Free radicals are formed as a part of normal metabolic activities but are neutralized by the
endogenous antioxidants present in cells/tissue, thus maintaining the redox balance. This …

Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer's disease: Past, present and future

F Gouveia, A Camins, M Ettcheto, J Bicker… - Ageing Research …, 2022 - Elsevier
Alzheimer's disease (AD) is a well-known neurodegenerative disease characterized by the
presence of two main hallmarks–Tau hyperphosphorylation and Aβ deposits …

Optical coherence tomography angiography in preclinical Alzheimer's disease

JA Van De Kreeke, HT Nguyen… - British Journal of …, 2020 - bjo.bmj.com
Background/aims As a protrusion from the brain, the retina might reflect the status of the
brain. Previous studies showed a decrease in vessel density and foveal avascular zone …

Toll‐Like Receptor 4: A Promising Therapeutic Target for Alzheimer's Disease

L Wu, X Xian, G Xu, Z Tan, F Dong… - Mediators of …, 2022 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disease that primarily
manifests as memory deficits and cognitive impairment and has created health challenges …

[HTML][HTML] MicroRNA-21 is a versatile regulator and potential treatment target in central nervous system disorders

X Bai, Z Bian - Frontiers in molecular neuroscience, 2022 - frontiersin.org
MicroRNAs (miRNAs) are a class of endogenous, non-coding, single-stranded RNAs with a
length of approximately 22 nucleotides that are found in eukaryotes. miRNAs are involved in …

Nanocarrier mediated drug delivery as an impeccable therapeutic approach against Alzheimer's disease

R Taliyan, V Kakoty, KC Sarathlal… - Journal of Controlled …, 2022 - Elsevier
For the past several years, dementia, is one of the predominantly observed groups of
symptoms in a geriatric population. Alzheimer's disease (AD) is a progressive memory …