Mitochondrial dysfunction and therapeutic perspectives in cardiovascular diseases

Y Liu, Y Huang, C Xu, P An, Y Luo, L Jiao… - International journal of …, 2022 - mdpi.com
High mortality rates due to cardiovascular diseases (CVDs) have attracted worldwide
attention. It has been reported that mitochondrial dysfunction is one of the most important …

Mitochondrial transfer as a novel therapeutic approach in disease diagnosis and treatment

VJ Clemente-Suárez, A Martín-Rodríguez… - International Journal of …, 2023 - mdpi.com
Mitochondrial dysfunction is a hallmark of numerous diseases, including neurodegenerative
disorders, metabolic disorders, and cancer. Mitochondrial transfer, the transfer of …

Enucleated oocyte donation: first for infertility treatment, then for mitochondrial diseases

G Pennings - Journal of Assisted Reproduction and Genetics, 2022 - Springer
There seems to be a consensus that enucleated oocyte donation (EOD) should only be used
to reduce the risk of having a child with mitochondrial disorders. However, this paper argues …

Early evidence of the artificial transfer/transplant of mitochondria to oocytes and zygotes by MitoCeption

F Cabrera, V Castañeda, E Morales, F Velarde… - Mitochondrion, 2022 - Elsevier
Oocytes may carry mutations in their mitochondrial DNA (mtDNA) which affect fertility and
embryo development leading to hereditary diseases or rejection. Mitochondrial replacement …

Ultrastructural evaluation of the human oocyte at the germinal vesicle stage during the application of assisted reproductive technologies

MG Palmerini, S Antonouli, G Macchiarelli, S Cecconi… - Cells, 2022 - mdpi.com
After its discovery in 1825 by the physiologist JE Purkinje, the human germinal vesicle (GV)
attracted the interest of scientists. Discarded after laparotomy or laparoscopic ovum pick up …

The mitochondrial genome in aging and disease and the future of mitochondrial therapeutics

S Saravanan, CJ Lewis, B Dixit, MS O'Connor… - Biomedicines, 2022 - mdpi.com
Mitochondria are intracellular organelles that utilize nutrients to generate energy in the form
of ATP by oxidative phosphorylation. Mitochondrial DNA (mtDNA) in humans is a 16,569 …

[HTML][HTML] Mitochondrial Mutations Affect the Cardiovascular System during Aging and Oxidative Stress

AV Poznyak, VN Sukhorukov, MА Popov… - Gene …, 2023 - xiahepublishing.com
Mitochondria are one of the most crucial components of the cell. Aging has a critical impact
on mitochondria. Various studies have shown that the relationship between aging and …

Emerging Multi-omic Approaches to the Molecular Diagnosis of Mitochondrial Disease and Available Strategies for Treatment and Prevention

F Khaghani, M Hemmati, M Ebrahimi… - Current …, 2024 - benthamdirect.com
Mitochondria are semi-autonomous organelles present in several copies within most cells in
the human body that are controlled by the precise collaboration of mitochondrial DNA …

Mito-TEMPO Improves the Meiosis Resumption and Mitochondrial Function of Vitrified Sheep Oocytes via the Recovery of Respiratory Chain Activity

X Zhao, A Dilixiati, L Zhang, A Aihemaiti, Y Song… - Animals, 2024 - mdpi.com
Simple Summary Vitrification causes oxidative stress and organelle damage in oocytes. The
results of this study reveal that Mito-TEMPO can efficaciously improve the oxidative stress …

The press-assisted fusion scheme significantly mitigates the quantity of HVJ-E required in mitochondrial replacement techniques

M Ma, S Jiang, W Jin, W Li, C Chen, K Lin… - …, 2024 - rep.bioscientifica.com
In brief: The impact of HVJ-E employed in mitochondrial replacement techniques (MRTs) on
embryonic development remains uncertain. This study has exhibited the influence of HVJ-E …