Fluorinated nucleosides: synthesis, modulation in conformation and therapeutic application

S Pal, G Chandra, S Patel, S Singh - The Chemical Record, 2022 - Wiley Online Library
Over the last twenty years, fluorination on nucleoside has established itself as the most
promising tool to use to get biologically active compounds that could sustain the clinical trial …

Recent progress on the synthesis of CF2H-containing derivatives

N Levi, D Amir, E Gershonov, Y Zafrani - Synthesis, 2019 - thieme-connect.com
Recent years have witnessed a growing interest in the development of novel synthetic
methods and new reagents for the synthesis of difluoromethylated compounds. Dozens of …

CF2H, a Functional Group-Dependent Hydrogen-Bond Donor: Is It a More or Less Lipophilic Bioisostere of OH, SH, and CH3?

Y Zafrani, G Sod-Moriah, D Yeffet… - Journal of Medicinal …, 2019 - ACS Publications
The effects of the CF2H moiety on H-bond (HB) acidity and lipophilicity of various
compounds, when attached directly to an aromatic ring or to other functions like alkyls …

Bi-functional hydrogen and coordination bonding surfactant: A novel and promising collector for improving the separation of calcium minerals

W Zhang, Z Feng, Y Yang, W Sun, S Pooley… - Journal of Colloid and …, 2021 - Elsevier
Mono-functional chelating collectors exhibit limited selectivity in the flotation of minerals. In
particular, the selective separation of calcium minerals presents a significant challenge …

The hydrogen bond: A hundred years and counting

S Scheiner - Journal of the Indian Institute of Science, 2020 - Springer
Since its original inception, a great deal has been learned about the nature, properties, and
applications of the H-bond. This review summarizes some of the unexpected paths that …

Modulation of the H-bond basicity of functional groups by α-fluorine-containing functions and its implications for lipophilicity and bioisosterism

Y Zafrani, G Parvari, D Amir… - Journal of Medicinal …, 2021 - ACS Publications
Modulation of the H-bond basicity (p K HB) of various functional groups (FGs) by attaching
fluorine functions and its impact on lipophilicity and bioisosterism considerations are …

i-Motif folding intermediates with zero-nucleotide loops are trapped by 2′-fluoroarabinocytidine via F··· H and O··· H hydrogen bonds

R El-Khoury, V Macaluso, C Hennecker… - Communications …, 2023 - nature.com
G-quadruplex and i-motif nucleic acid structures are believed to fold through kinetic
partitioning mechanisms. Such mechanisms explain the structural heterogeneity of G …

Enhanced mechanical and thermal properties of polyamide 6/p (N-(4-F-phenylmaleimide)–alt-styrene) composites based on interfacial complexation inducing crystal …

Y Liu, S Jiang, W Yan, J Qin, M He, S Qin, J Yu - Polymer, 2021 - Elsevier
Highlights•The interfacial complexation of PFS with PA6 was proved.•The crystal
transformation of PA6 from γ-crystal to α-crystal was proved.•The HDT of the PA6/PFS-10 …

Improving LMOF luminescence quantum yield through guest-mediated rigidification

WP Lustig, SJ Teat, J Li - Journal of Materials Chemistry C, 2019 - pubs.rsc.org
Luminescent metal–organic frameworks (LMOFs) are among the fastest growing solid-state
optical materials and have been studied for a wide variety of applications. However, when …

Nucleoside Analogues with a seven-membered sugar ring: synthesis and structural compatibility in DNA–RNA hybrids

SK Jana, S Harikrishna, S Sudhakar… - The Journal of …, 2022 - ACS Publications
Herein we describe results on the pairing properties of synthetic DNA and RNA
oligonucleotides that contain nucleotide analogues with a 7-membered sugar ring (oxepane …