Interplay between PI3K/AKT pathway and heart disorders

S Ghafouri-Fard, A Khanbabapour Sasi… - Molecular biology …, 2022 - Springer
Abstract The PI3K/AKT signaling has crucial role in the regulation of numerous physiological
functions through activation of downstream effectors and modulation of cell cycle transition …

Dormancy, stemness, and therapy resistance: interconnected players in cancer evolution

F Francescangeli, ML De Angelis, R Rossi… - Cancer and Metastasis …, 2023 - Springer
The biological complexity of cancer represents a tremendous clinical challenge, resulting in
the frequent failure of current treatment protocols. In the rapidly evolving scenario of a …

Role of PI3K/AKT pathway in squamous cell carcinoma with an especial focus on head and neck cancers

S Ghafouri-Fard, A Noie Alamdari… - Cancer Cell …, 2022 - Springer
Abstract PI3K/AKT pathway is an important pathway in the carcinogenesis since it has
central impacts in the regulation of metabolic pathways, cell proliferation and survival, gene …

Resveratrol alleviates dextran sulfate sodium-induced acute ulcerative colitis in mice by mediating PI3K/Akt/VEGFA pathway

F Zhu, J Zheng, F Xu, Y Xi, J Chen, X Xu - Frontiers in Pharmacology, 2021 - frontiersin.org
Ulcerative colitis (UC) is a chronic inflammatory disease that affects the colon, and its
incidence is on the rise worldwide. Resveratrol (RSV), a polyphenolic compound, was …

Role of endometrial microRNAs in repeated implantation failure (mini-review)

S Goharitaban, A Abedelahi, K Hamdi… - Frontiers in Cell and …, 2022 - frontiersin.org
MicroRNAs (miRNAs) play various roles in the implantation and pregnancy process.
Abnormal regulation of miRNAs leads to reproductive disorders such as repeated …

Multiple function of lncRNA MALAT1 in cancer occurrence and progression

F Malakoti, N Targhazeh, H Karimzadeh… - Chemical biology & …, 2023 - Wiley Online Library
Long non‐coding RNAs (lncRNAs) have received particular attention in the last decade due
to its engaging in carcinogenesis and tumorigenesis. Metastasis‐associated lung …

Role of m6A modification in regulating the PI3K/AKT signaling pathway in cancer

J Liu, X Gu, Z Guan, D Huang, H Xing… - Journal of Translational …, 2023 - Springer
Abstract The phosphoinositide 3-kinase (PI3K)/AKT signaling pathway plays a crucial role in
the pathogenesis of cancer. The dysregulation of this pathway has been linked to the …

LncRNAs and PTEN/PI3K signaling: A symphony of regulation in cancer biology

WH Almalki - Pathology-Research and Practice, 2023 - Elsevier
Abstract The Emergence of Long Non-coding RNAs (lncRNAs) as Key Regulators in Diverse
Biological Processes: A Paradigm Shift in Understanding Gene Expression and its Impact on …

[HTML][HTML] MIR503HG: A potential diagnostic and therapeutic target in human diseases

X Han, B Li, S Zhang - Biomedicine & Pharmacotherapy, 2023 - Elsevier
LncRNAs are involved in many physiological and pathological processes, including
chromatin remodeling, transcription, posttranscriptional gene expression, mRNA stability …

Desmoglein2 regulates Claudin2 expression by sequestering PI-3-Kinase in intestinal epithelial cells

N Burkard, M Meir, F Kannapin, C Otto… - Frontiers in …, 2021 - frontiersin.org
Inflammation-induced reduction of intestinal desmosomal cadherin Desmoglein 2 (Dsg2) is
linked to changes of tight junctions (TJ) leading to impaired intestinal epithelial barrier (IEB) …