[HTML][HTML] Targeting the latent reservoir for HIV-1
S Sengupta, RF Siliciano - Immunity, 2018 - cell.com
Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
International AIDS Society global scientific strategy: towards an HIV cure 2016
Antiretroviral therapy is not curative. Given the challenges in providing lifelong therapy to a
global population of more than 35 million people living with HIV, there is intense interest in …
global population of more than 35 million people living with HIV, there is intense interest in …
[HTML][HTML] Identification of genetically intact HIV-1 proviruses in specific CD4+ T cells from effectively treated participants
Latent replication-competent HIV-1 persists in individuals on long-term antiretroviral therapy
(ART). We developed the Full-Length Individual Proviral Sequencing (FLIPS) assay to …
(ART). We developed the Full-Length Individual Proviral Sequencing (FLIPS) assay to …
[HTML][HTML] The HIV reservoir in monocytes and macrophages
ME Wong, A Jaworowski, AC Hearps - Frontiers in immunology, 2019 - frontiersin.org
In people living with HIV (PLWH) who are failing or unable to access combination
antiretroviral therapy (cART), monocytes and macrophages are important drivers of …
antiretroviral therapy (cART), monocytes and macrophages are important drivers of …
Specific HIV integration sites are linked to clonal expansion and persistence of infected cells
F Maldarelli, X Wu, L Su, FR Simonetti, W Shao, S Hill… - Science, 2014 - science.org
The persistence of HIV-infected cells in individuals on suppressive combination antiretroviral
therapy (cART) presents a major barrier for curing HIV infections. HIV integrates its DNA into …
therapy (cART) presents a major barrier for curing HIV infections. HIV integrates its DNA into …
[HTML][HTML] HIV persists throughout deep tissues with repopulation from multiple anatomical sources
BACKGROUND Understanding HIV dynamics across the human body is important for cure
efforts. This goal has been hampered by technical difficulties and the challenge of obtaining …
efforts. This goal has been hampered by technical difficulties and the challenge of obtaining …
Defective HIV-1 proviruses produce novel protein-coding RNA species in HIV-infected patients on combination antiretroviral therapy
H Imamichi, RL Dewar… - Proceedings of the …, 2016 - National Acad Sciences
Despite years of plasma HIV-RNA levels< 40 copies per milliliter during combination
antiretroviral therapy (cART), the majority of HIV-infected patients exhibit persistent …
antiretroviral therapy (cART), the majority of HIV-infected patients exhibit persistent …
[HTML][HTML] HIV-1 integration landscape during latent and active infection
The barrier to curing HIV-1 is thought to reside primarily in CD4+ T cells containing silent
proviruses. To characterize these latently infected cells, we studied the integration profile of …
proviruses. To characterize these latently infected cells, we studied the integration profile of …
[HTML][HTML] The HIV-1 proviral landscape reveals that Nef contributes to HIV-1 persistence in effector memory CD4+ T cells
G Duette, B Hiener, H Morgan… - The Journal of …, 2022 - Am Soc Clin Investig
Despite long-term antiretroviral therapy (ART), HIV-1 persists within a reservoir of CD4+ T
cells that contribute to viral rebound if treatment is interrupted. Identifying the cellular …
cells that contribute to viral rebound if treatment is interrupted. Identifying the cellular …
[HTML][HTML] Clonal expansion of genome-intact HIV-1 in functionally polarized Th1 CD4+ T cells
HIV-1 causes a chronic, incurable disease due to its persistence in CD4+ T cells that contain
replication-competent provirus, but exhibit little or no active viral gene expression and …
replication-competent provirus, but exhibit little or no active viral gene expression and …