Restricting retrotransposons: a review
JL Goodier - Mobile DNA, 2016 - Springer
Retrotransposons have generated about 40% of the human genome. This review examines
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …
[HTML][HTML] From APOBEC to ZAP: Diverse mechanisms used by cellular restriction factors to inhibit virus infections
M Chemudupati, AD Kenney, S Bonifati, A Zani… - … Et Biophysica Acta (BBA …, 2019 - Elsevier
Antiviral restriction factors are cellular proteins that inhibit the entry, replication, or spread of
viruses. These proteins are critical components of the innate immune system and function to …
viruses. These proteins are critical components of the innate immune system and function to …
The ribonuclease activity of SAMHD1 is required for HIV-1 restriction
The HIV-1 restriction factor SAM domain–and HD domain–containing protein 1 (SAMHD1),
is proposed to inhibit HIV-1 replication by depleting the intracellular dNTP pool,,. However …
is proposed to inhibit HIV-1 replication by depleting the intracellular dNTP pool,,. However …
SAMHD1 promotes DNA end resection to facilitate DNA repair by homologous recombination
W Daddacha, AE Koyen, AJ Bastien, PSE Head… - Cell reports, 2017 - cell.com
DNA double-strand break (DSB) repair by homologous recombination (HR) is initiated by
CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP …
CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP …
Structural basis of cellular dNTP regulation by SAMHD1
The sterile alpha motif and HD domain-containing protein 1 (SAMHD1), a dNTPase,
prevents the infection of nondividing cells by retroviruses, including HIV, by depleting the …
prevents the infection of nondividing cells by retroviruses, including HIV, by depleting the …
Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance
M Rentoft, K Lindell, P Tran… - Proceedings of the …, 2016 - National Acad Sciences
Even small variations in dNTP concentrations decrease DNA replication fidelity, and this
observation prompted us to analyze genomic cancer data for mutations in enzymes involved …
observation prompted us to analyze genomic cancer data for mutations in enzymes involved …
SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity
KJ Seamon, Z Sun, LS Shlyakhtenko… - Nucleic acids …, 2015 - academic.oup.com
The HIV-1 restriction factor SAMHD1 is a tetrameric enzyme activated by guanine
nucleotides with dNTP triphosphate hydrolase activity (dNTPase). In addition to this …
nucleotides with dNTP triphosphate hydrolase activity (dNTPase). In addition to this …
SAMHD1 functions and human diseases
SAA Coggins, B Mahboubi, RF Schinazi, B Kim - Viruses, 2020 - mdpi.com
Deoxynucleoside triphosphate (dNTP) molecules are essential for the replication and
maintenance of genomic information in both cells and a variety of viral pathogens. While the …
maintenance of genomic information in both cells and a variety of viral pathogens. While the …
Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications
R Kohnken, KM Kodigepalli, L Wu - Molecular cancer, 2015 - Springer
Regulation of intracellular deoxynucleoside triphosphate (dNTP) pool is critical to genomic
stability and cancer development. Imbalanced dNTP pools can lead to enhanced …
stability and cancer development. Imbalanced dNTP pools can lead to enhanced …
SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks
Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) has a dNTPase-
independent function in promoting DNA end resection to facilitate DNA double-strand break …
independent function in promoting DNA end resection to facilitate DNA double-strand break …