The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives

C d'Enfert, AK Kaune, LR Alaban… - FEMS microbiology …, 2021 - academic.oup.com
Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …

Immune defence against Candida fungal infections

MG Netea, LAB Joosten, JWM Van Der Meer… - Nature Reviews …, 2015 - nature.com
The immune response to Candida species is shaped by the commensal character of the
fungus. There is a crucial role for discerning between colonization and invasion at mucosal …

Candida glabrata, Candida parapsilosis and Candida tropicalis: biology, epidemiology, pathogenicity and antifungal resistance

S Silva, M Negri, M Henriques, R Oliveira… - FEMS microbiology …, 2012 - academic.oup.com
The incidence of infections caused by Candida species (candidosis) has increased
considerably over the past three decades, mainly due to the rise of the AIDS epidemic, an …

Candida albicans morphogenesis and host defence: discriminating invasion from colonization

NAR Gow, FL Van De Veerdonk, AJP Brown… - Nature reviews …, 2012 - nature.com
Candida albicans is a common fungal pathogen of humans that colonizes the skin and
mucosal surfaces of most healthy individuals. Until recently, little was known about the …

Candida albicans promotes tooth decay by inducing oral microbial dysbiosis

Q Du, B Ren, J He, X Peng, Q Guo, L Zheng… - The ISME …, 2021 - academic.oup.com
Candida albicans has been detected in root carious lesions. The current study aimed to
explore the action of this fungal species on the microbial ecology and the pathogenesis of …

Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota

S Höfs, S Mogavero, B Hube - Journal of microbiology, 2016 - Springer
The interaction between Candida albicans and its host cells is characterized by a complex
interplay between the expression of fungal virulence factors, which results in adherence …

Candida and Candidiasis—Opportunism Versus Pathogenicity: A Review of the Virulence Traits

CN Ciurea, IB Kosovski, AD Mare, F Toma… - Microorganisms, 2020 - mdpi.com
One of the most important questions in microbiology nowadays, is how apparently harmless,
commensal yeasts like Candida spp. can cause a rising number of infections. The …

Candida albicans Secreted Aspartyl Proteinases in Virulence and Pathogenesis

JR Naglik, SJ Challacombe, B Hube - Microbiology and molecular …, 2003 - Am Soc Microbiol
Candida albicans is the most common fungal pathogen of humans and has developed an
extensive repertoire of putative virulence mechanisms that allows successful colonization …

Candida albicans dimorphism as a therapeutic target

ID Jacobsen, D Wilson, B Wächtler… - Expert review of anti …, 2012 - Taylor & Francis
The ability to switch between yeast and hyphal growth forms (dimorphism) is one of the most
discussed and best investigated virulence attributes of the human pathogenic fungus …

Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms

CF Urban, U Reichard, V Brinkmann… - Cellular …, 2006 - Wiley Online Library
Neutrophils phagocytose and kill microbes upon phagolysosomal fusion. Recently we found
that activated neutrophils form extracellular fibres that consist of granule proteins and …