Metabolic syndrome: updates on pathophysiology and management in 2021

G Fahed, L Aoun, M Bou Zerdan, S Allam… - International journal of …, 2022 - mdpi.com
Metabolic syndrome (MetS) forms a cluster of metabolic dysregulations including insulin
resistance, atherogenic dyslipidemia, central obesity, and hypertension. The pathogenesis …

Oxidative-stress-related genes in osteoporosis: a systematic review

G León-Reyes, AD Argoty-Pantoja, A Becerra-Cervera… - Antioxidants, 2023 - mdpi.com
Osteoporosis is characterized by a decline in bone mineral density (BMD) and increased
fracture risk. Free radicals and antioxidant systems play a central role in bone remodeling …

Comprehensive genetic study of the insulin resistance marker TG: HDL-C in the UK Biobank

A Oliveri, RJ Rebernick, A Kuppa, A Pant, Y Chen… - Nature …, 2024 - nature.com
Insulin resistance (IR) is a well-established risk factor for metabolic disease. The ratio of
triglycerides to high-density lipoprotein cholesterol (TG: HDL-C) is a surrogate marker of IR …

Genome-wide association study of the metabolic syndrome in UK biobank

L Lind - Metabolic syndrome and related disorders, 2019 - liebertpub.com
Abstract Background: The metabolic syndrome (MetS) is a description of a clustering of
cardiometabolic risk factors in the same individual. Previous genome-wide association …

Body roundness index is a superior indicator to associate with the cardio‐metabolic risk: evidence from a cross‐sectional study with 17,000 Eastern-China adults

J Xu, L Zhang, Q Wu, Y Zhou, Z Jin, Z Li… - BMC cardiovascular …, 2021 - Springer
Background To investigate the ability of body shape index (ABSI), body roundness index
(BRI), waist circumference (WC), body mass index (BMI), waist-to-hip ratio (WHR), waist-to …

Twenty-five novel loci for carotid intima-media thickness: a genome-wide association study in> 45 000 individuals and meta-analysis of> 100 000 individuals

MW Yeung, S Wang, YJ van de Vegte… - … , and vascular biology, 2022 - Am Heart Assoc
Objective: Carotid artery intima-media thickness (cIMT) is a widely accepted marker of
subclinical atherosclerosis. Twenty susceptibility loci for cIMT were previously identified and …

[HTML][HTML] Causal associations of alcohol consumption with cardiovascular diseases and all-cause mortality among Chinese males

C Hu, C Huang, J Li, F Liu, K Huang, Z Liu… - The American journal of …, 2022 - Elsevier
Background The causal effects of moderate alcohol consumption on cardiovascular
diseases (CVDs) are continuously debated, especially on coronary artery disease (CAD) …

Multi-stage metabolomics and genetic analyses identified metabolite biomarkers of metabolic syndrome and their genetic determinants

Q Wu, J Li, X Sun, D He, Z Cheng, J Li, X Zhang… - …, 2021 - thelancet.com
Abstract Background Metabolic syndrome (MetS) is a cluster of multiple cardiometabolic risk
factors that increase the risk of type 2 diabetes and cardiovascular diseases. Identifying …

Whole-genome sequencing of half-a-million UK Biobank participants

UK Biobank Whole-Genome Sequencing Consortium… - medRxiv, 2023 - medrxiv.org
Whole-genome sequencing (WGS) provides a comprehensive view of the genome, enabling
detection of coding and non-coding genetic variation, and surveying complex regions which …

Gamma-glutamyl-leucine levels are causally associated with elevated cardio-metabolic risks

Q Wu, J Li, J Zhu, X Sun, D He, J Li, Z Cheng… - Frontiers in …, 2022 - frontiersin.org
Objective Gamma-glutamyl dipeptides are bioactive peptides involved in inflammation,
oxidative stress, and glucose regulation. Gamma-glutamyl-leucine (Gamma-Glu-Leu) has …