Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia in the elderly, and affects
millions of people worldwide. As the number of AD cases continues to increase in both …
millions of people worldwide. As the number of AD cases continues to increase in both …
Histone deacetylases in memory and cognition
Over the past 30 years, lysine acetylation of histone and nonhistone proteins has become
established as a key modulator of gene expression regulating numerous aspects of cell …
established as a key modulator of gene expression regulating numerous aspects of cell …
[HTML][HTML] Declining levels of functionally specialized synaptic proteins in plasma neuronal exosomes with progression of Alzheimer's disease
Interactions of the presynaptic proteins, neuronal pentraxin 2 (NPTX2) and neurexin 2α
(NRXN2α), with their respective postsynaptic functional partners, GluA4-containing …
(NRXN2α), with their respective postsynaptic functional partners, GluA4-containing …
A proinflammatory stimulus disrupts hippocampal plasticity and learning via microglial activation and 25-hydroxycholesterol
Y Izumi, AG Cashikar, K Krishnan, SM Paul… - Journal of …, 2021 - Soc Neuroscience
Inflammatory cells, including macrophages and microglia, synthesize and release the
oxysterol 25-hydroxycholesterol (25HC), which has antiviral and immunomodulatory …
oxysterol 25-hydroxycholesterol (25HC), which has antiviral and immunomodulatory …
Reversal of synapse degeneration by restoring Wnt signaling in the adult hippocampus
Synapse degeneration occurs early in neurodegenerative diseases and correlates strongly
with cognitive decline in Alzheimer's disease (AD). The molecular mechanisms that trigger …
with cognitive decline in Alzheimer's disease (AD). The molecular mechanisms that trigger …
New roles for Fc receptors in neurodegeneration-the impact on Immunotherapy for Alzheimer's Disease
JP Fuller, JB Stavenhagen, JL Teeling - Frontiers in neuroscience, 2014 - frontiersin.org
There are an estimated 18 million Alzheimer's disease (AD) sufferers worldwide and with no
disease modifying treatment currently available, development of new therapies represents …
disease modifying treatment currently available, development of new therapies represents …
Recent advances in the mechanisms of neuroinflammation and their roles in neurodegeneration
R Niranjan - Neurochemistry international, 2018 - Elsevier
Neuroinflammation is associated with the pathogenesis of many neurological disorders
including Parkinson's disease, Alzheimer's disease, Amyotrophic lateral sclerosis and …
including Parkinson's disease, Alzheimer's disease, Amyotrophic lateral sclerosis and …
Functional significance of rare neuroligin 1 variants found in autism
M Nakanishi, J Nomura, X Ji, K Tamada, T Arai… - PLoS …, 2017 - journals.plos.org
Genetic mutations contribute to the etiology of autism spectrum disorder (ASD), a common,
heterogeneous neurodevelopmental disorder characterized by impairments in social …
heterogeneous neurodevelopmental disorder characterized by impairments in social …
Cross talk between brain innate immunity and serotonin signaling underlies depressive-like behavior induced by Alzheimer's amyloid-β oligomers in mice
Considerable clinical and epidemiological evidence links Alzheimer's disease (AD) and
depression. However, the molecular mechanisms underlying this connection are largely …
depression. However, the molecular mechanisms underlying this connection are largely …
[11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer's disease
Alzheimer's disease (AD) is characterized by the brain accumulation of amyloid-β and tau
proteins. A growing body of literature suggests that epigenetic dysregulations play a role in …
proteins. A growing body of literature suggests that epigenetic dysregulations play a role in …