The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian
cells and serves to regulate a multitude of physiological processes has continued to …

Since the introduction of the cancer stem cell (CSC) paradigm, significant advances have
been made in understanding the functional and biological plasticity of these elusive …

Thirty years after the discovery of its production by activated macrophages, our appreciation
of the diverse roles of nitric oxide (NO) continues to grow. Recent findings have not only …

The three endogenous gaseous transmitters—nitric oxide (NO), carbon monoxide (CO) and
hydrogen sulfide (H2S)—regulate a number of key biological functions. Emerging data have …

Glioblastoma (GBM) is one of the most aggressive and lethal human brain tumors. At
present, GBMs are divided in primary and secondary on the basis of the mutational status of …

Cancer stem cells (CSCs), known also as tumor-initiating cells, are quiescent, pluripotent,
self-renewing neoplastic cells that were first identified in hematologic tumors and soon after …

It is widely accepted that dynamic and reversible tumour cell plasticity is required for
metastasis, however, in vivo steps and molecular mechanisms are poorly elucidated. We …

The cancer stem cell (CSC) model has been established as a cellular mechanism that
contributes to phenotypic and functional heterogeneity in diverse cancer types. Recent …

Brain tumor initiating cells (BTICs) co-opt the neuronal high affinity glucose transporter,
GLUT3, to withstand metabolic stress. We investigated another mechanism critical to brain …

Abstract CD133 (prominin-1), a pentaspan membrane glycoprotein, is one of the most well-
characterized biomarkers used for the isolation of cancer stem cells (CSCs). The presence …