The link between obesity, microbiota dysbiosis, and neurodegenerative pathogenesis

E Vamanu, SN Rai - Diseases, 2021 - mdpi.com
Current research in medicine in several parts of the world has attempted to establish a link
between the occurrence of neurodegenerative pathologies, microbiota dysbiosis, and the …

The pathogenesis and pathophysiology of gestational diabetes mellitus: Deductions from a three-part longitudinal metabolomics study in China

KP Law, H Zhang - Clinica Chimica Acta, 2017 - Elsevier
Gestational diabetes mellitus (GDM) is a form of diabetes that is first recognised during
pregnancy, with no evidence of pre-existing type 1 or type 2 diabetes. The prevalence of …

MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation

Z Pang, Y Lu, G Zhou, F Hui, L Xu, C Viau… - Nucleic Acids …, 2024 - academic.oup.com
We introduce MetaboAnalyst version 6.0 as a unified platform for processing, analyzing, and
interpreting data from targeted as well as untargeted metabolomics studies using liquid …

Plasma amino acids metabolomics' important in glucose management in type 2 diabetes

A Alqudah, M Wedyan, E Qnais, H Jawarneh… - Frontiers in …, 2021 - frontiersin.org
The perturbation in plasma free amino acid metabolome has been observed previously in
diabetes mellitus, and is associated with insulin resistance as well as the onset of …

Association of tryptophan metabolites with incident type 2 diabetes in the PREDIMED trial: a case–cohort study

E Yu, C Papandreou, M Ruiz-Canela… - Clinical …, 2018 - academic.oup.com
BACKGROUND Metabolites of the tryptophan–kynurenine pathway (ie, tryptophan,
kynurenine, kynurenic acid, quinolinic acid, 3-hydroxyanthranilic) may be associated with …

Tryptophan and purine metabolites are consistently upregulated in the urinary metabolome of patients diagnosed with gestational diabetes mellitus throughout …

KP Law, TL Han, X Mao, H Zhang - Clinica chimica acta, 2017 - Elsevier
Background Gestational diabetes mellitus (GDM) is a pathological state of glucose
intolerance associated with adverse pregnancy outcomes and an increased risk of …

Tryptophan metabolism in atherosclerosis and diabetes

E Sudar-Milovanovic, Z Gluvic… - Current Medicinal …, 2022 - ingentaconnect.com
The essential amino acid tryptophan (Trp) undergoes catabolism through several pathways,
producing biologically active metabolites that significantly impact physiological processes …

Metabolomics in gestational diabetes

X Mao, X Chen, C Chen, H Zhang, KP Law - Clinica chimica acta, 2017 - Elsevier
Gestational diabetes mellitus (GDM) is a form of diabetes that is first diagnosed during
pregnancy in the absence of existing type 1 or type 2 diabetes. Early screening tools for …

Interactions of apigenin and safranal with the 5HT1A and 5HT2A receptors and behavioral effects in depression and anxiety: a molecular docking, lipid-mediated …

F Amin, MAA Ibrahim, S Rizwan-ul-Hasan, S Khaliq… - Molecules, 2022 - mdpi.com
Background: The current study utilizes in silico molecular docking/molecular dynamics to
evaluate the binding affinity of apigenin and safranal with 5HT1AR/5HT2AR, followed by …

Serum amino acids in association with prevalent and incident type 2 diabetes in a Chinese population

Y Lu, Y Wang, X Liang, L Zou, CN Ong, JM Yuan… - Metabolites, 2019 - mdpi.com
We aimed to simultaneously examine the associations of both essential and non-essential
amino acids with both prevalent and incident type 2 diabetes in a Chinese population. A …