Since the dawn of space exploration, the survivability of terrestrial life in outer space
conditions has attracted enormous attention. Space technology has enabled the …

In recent years, mass spectrometry (MS)-based metabolomics has been extensively applied
to characterize biochemical mechanisms, and study physiological processes and …

Motivation One central goal of systems biology is to infer biochemical regulations from large-
scale OMICS data. Many aspects of cellular physiology and organismal phenotypes can be …

During the progression of complex diseases caused by qualitative shifts in gene networks,
the deteriorations may be abrupt and cause a critical transition from a healthy state to a …

System theory has its roots in mathematical formalisms developed by mathematicians and
physicists, such as Leibniz, Euler, and Newton, and applied by congenial chemists and …

Inspired by Waddington's illustration of an epigenetic landscape, cell-fate transitions have
been envisioned as bifurcating dynamical systems, wherein exogenous signaling dynamics …

Recent advances in metabolomics technologies have resulted in high-quality (time-
resolved) metabolic profiles with an increasing coverage of metabolic pathways. These data …

There is a critical transition before a high-dimensional network system completely
deteriorates. The Dynamical Network Marker (DNM) theory has been developed for the early …

Reverse engineering metabolome data to infer metabolic interactions is a challenging
research topic. Here we introduce JacLy, a Jacobian-based method to infer metabolic …

The development of next-generation sequencing and single-cell technology has generated
vast genome-scale multi-omics datasets. Dedicated mathematical algorithms are required to …