The hypoxic tumour is a chaotic landscape of struggle and adaption. Against the adversity of
oxygen starvation, hypoxic cancer cells initiate a reprogramming of transcriptional activities …

Today, cancer still poses a serious threat to human, but there is no exact cure. Therefore,
exploring to accomplish high therapeutic performance is a challenging and urgent task …

More than half of cancer patients are treated with radiotherapy, which kills tumor cells by
directly and indirectly inducing DNA damage, including cytotoxic DNA double-strand breaks …

Introduction Glioblastoma (GBM) is the most lethal primary malignant brain tumor in adults
with poor survival due to acquired therapeutic resistance and rapid recurrence. Currently …

Simple Summary Hypoxia is a common feature of lung cancers. Nonetheless, no guidelines
have been established to integrate hypoxia-associated biomarkers in patient management …

Purpose Strategies to increase radiosensitivity are urgently needed. Combining
radiosensitizing reagents with radiotherapy could improve the outcome of cancer treatment …

Abstract Receptor Tyrosine Kinases (RTK) are an important family involved in numerous
signaling pathways essential for proliferation, cell survival, transcription or cell-cycle …

Fig. 1 Potential cellular targets to radiosensitize lung tumor cells. The figure highlights a
number of proteins that mediate (1) cellular growth and survival,(2) apoptosis,(3) cell cycle …

Discovery of effective radiosensitization strategies that improve the therapeutic ratio for
patients with lung cancer has been a goal of researchers and an area of vigorous …

The hypoxic tumour is a chaotic landscape of struggle and adaption. Against the adversity of
oxygen starvation, hypoxic cancer cells initiate a reprogramming of transcriptional activities …