Whole genome sequencing of Mycobacterium tuberculosis: current standards and open issues
Whole genome sequencing (WGS) of Mycobacterium tuberculosis has rapidly progressed
from a research tool to a clinical application for the diagnosis and management of …
from a research tool to a clinical application for the diagnosis and management of …
Evolution and emergence of Mycobacterium tuberculosis
M Orgeur, C Sous, J Madacki… - FEMS Microbiology …, 2024 - academic.oup.com
Tuberculosis (TB) remains one of the deadliest infectious diseases in human history,
prevailing even in the 21st century. The causative agents of TB are represented by a group …
prevailing even in the 21st century. The causative agents of TB are represented by a group …
Transcontinental spread and evolution of Mycobacterium tuberculosis W148 European/Russian clade toward extensively drug resistant tuberculosis
Transmission-driven multi-/extensively drug resistant (M/XDR) tuberculosis (TB) is the
largest single contributor to human mortality due to antimicrobial resistance. A few major …
largest single contributor to human mortality due to antimicrobial resistance. A few major …
Population-level emergence of bedaquiline and clofazimine resistance-associated variants among patients with drug-resistant tuberculosis in southern Africa: a …
Background Bedaquiline and clofazimine are important drugs in the treatment of drug-
resistant tuberculosis and are commonly used across southern Africa, although drug …
resistant tuberculosis and are commonly used across southern Africa, although drug …
The molecular clock of Mycobacterium tuberculosis
The molecular clock and its phylogenetic applications to genomic data have changed how
we study and understand one of the major human pathogens, Mycobacterium tuberculosis …
we study and understand one of the major human pathogens, Mycobacterium tuberculosis …
Genomic signatures of pre-resistance in Mycobacterium tuberculosis
A Torres Ortiz, J Coronel, JR Vidal, C Bonilla… - Nature …, 2021 - nature.com
Recent advances in bacterial whole-genome sequencing have resulted in a comprehensive
catalog of antibiotic resistance genomic signatures in Mycobacterium tuberculosis. With a …
catalog of antibiotic resistance genomic signatures in Mycobacterium tuberculosis. With a …
The Mycobacterium tuberculosis genome at 25 years: lessons and lingering questions
BN Koleske, WR Jacobs… - The Journal of clinical …, 2023 - Am Soc Clin Investig
First achieved in 1998 by Cole et al., the complete genome sequence of Mycobacterium
tuberculosis continues to provide an invaluable resource to understand tuberculosis (TB) …
tuberculosis continues to provide an invaluable resource to understand tuberculosis (TB) …
Phylogeography and transmission of Mycobacterium tuberculosis spanning prisons and surrounding communities in Paraguay
Recent rises in incident tuberculosis (TB) cases in Paraguay and the increasing
concentration of TB within prisons highlight the urgency of targeting strategies to interrupt …
concentration of TB within prisons highlight the urgency of targeting strategies to interrupt …
Investigating the composition and recruitment of the mycobacterial ImuA′–ImuB–DnaE2 mutasome
A DNA damage-inducible mutagenic gene cassette has been implicated in the emergence
of drug resistance in Mycobacterium tuberculosis during anti-tuberculosis (TB) …
of drug resistance in Mycobacterium tuberculosis during anti-tuberculosis (TB) …
A seventeenth-century Mycobacterium tuberculosis genome supports a Neolithic emergence of the Mycobacterium tuberculosis complex
Background Although tuberculosis accounts for the highest mortality from a bacterial
infection on a global scale, questions persist regarding its origin. One hypothesis based on …
infection on a global scale, questions persist regarding its origin. One hypothesis based on …