Sepsis is a frequent complication in immunosuppressed cancer patients and hematopoietic
stem cell transplant recipients that is associated with high morbidity and mortality rates. The …

Background The optimization of the use of β-lactam antibiotics (BLA) via prolonged infusions
in life-threatening complications such as febrile neutropenia (FN) is still controversial. This …

Objectives The objectives of this study were to describe piperacillin exposure in febrile
neutropenia patients and determine whether therapeutic drug monitoring (TDM) can be …

Bacterial infection is one of the most frequent complications in cancer patients and
hematopoietic stem cell transplant recipients. In recent years, the emergence of …

Haematologica has published European guidelines for empirical and targeted antibacterial
therapy for febrile neutropenic patients in the era of emerging resistance (ECIL-4). Indeed …

Objectives Information on the efficacy of extended meropenem administration in neutropenic
patients is scarce. Our objective was to determine whether the administration of meropenem …

Infections due to resistant and multidrug resistant (MDR) organisms in haematology patients
and haematopoietic stem cell transplant recipients are an increasingly complex problem of …

Managing cancer patients with fever and neutropenia must be considered as a medical
emergency since any delay in initiating appropriate empirical antibacterial therapy may …

This study assessed the pharmacokinetics and dosing adequacy of piperacillin in febrile
neutropenic patients after the first dose. Pharmacokinetic analysis was performed using …

Changes in the pharmacokinetics of piperacillin in febrile neutropenic patients have been
reported to result in suboptimal exposures. This study aimed to develop a population …