The genome is constantly attacked by genotoxic insults. DNA damage has long been
established as a cause of cancer development through its mutagenic consequences …

Several epidemiological studies show an inverse association between cancer and
Alzheimer's disease (AD). It is debated whether this association is the consequence of …

p53 is primarily known as a downstream transcriptional effector in the DNA damage-
response cascade. We report that endogenous p53 rapidly accumulates at DNA damage …

DNA damage can induce a tumor suppressive response termed cellular senescence.
Damaged senescent cells permanently arrest growth, secrete inflammatory cytokines and …

The p53 tumor suppressor protein, often termed guardian of the genome, integrates diverse
physiological signals in mammalian cells. In response to stress signals, perhaps the best …

Ruthenium (II)-based coordination complexes have emerged as photosensitizers (PSs) for
photodynamic therapy (PDT) in oncology as well as antimicrobial indications and have great …

DNA in live cells undergoes continuous oxidative damage caused by metabolically
generated endogenous as well as external oxidants and oxidant-inducers. The cumulative …

Ionizing radiation triggers diverse responses in human cells encompassing apoptosis,
necrosis, stress-induced premature senescence (SIPS), autophagy, and endopolyploidy (eg …

The mechanism by which p53 suppresses tumorigenesis remains poorly understood. In the
context of aberrant activation of the JAK/STAT5 pathway, SOCS1 is required for p53 …

Hypoxic cells have been linked to genetic instability and tumor progression. However, little is
known about the exact relationship between DNA repair and genetic instability in hypoxic …