Abstract Sp1 (specificity protein 1) is a well-known member of a family of transcription factors
that also includes Sp2, Sp3 and Sp4, which are implicated in an ample variety of essential …

Cancer is a multifactorial disease, and therefore, a multitarget approach is needed to face
the complex cancer biology, based on the combined use of different natural and synthetic …

Our goal of this study was to reconstruct a “genome-scale co-expression network” and find
important modules in lung adenocarcinoma so that we could identify the genes involved in …

Background It's been 50 years since chemotherapy was introduced into the clinical practice
of cancer treatment. Chemotherapy has been successful in the treatment of some forms of …

Naturally occurring anticancer agents and their derivatives act on multiple pathways to
inhibit carcinogenesis and their inhibition of migration, invasion, growth, survival, and …

Non-steroidal anti-inflammatory drugs (NSAIDs) are used extensively for analgesic and
antipyretic treatments. In addition, NSAIDs reduce the risk and mortality to several cancers …

Introduction: Specificity protein (Sp) transcription factors (TFs) are members of the
Sp/Kruppel-like factor family, and Sp proteins play an important role in embryonic and early …

In the past decade, we have observed exciting advances in lung cancer therapy, including
the development of targeted therapies. However, additional strategies for early detection …

Inflammation is considered the root cause of various inflammatory diseases, including
cancers. Decursinol angelate (DA), a pyranocoumarin compound obtained from the roots of …

Bufalin, a naturally occurring small-molecule compound from Traditional Chinese Medicine
(TCM) Chansu showed inhibitory effects against human prostate, hepatocellular …