The gut microbiome and hypertension

JA O'Donnell, T Zheng, G Meric… - Nature Reviews …, 2023 - nature.com
A large body of evidence has emerged in the past decade supporting a role for the gut
microbiome in the regulation of blood pressure. The field has moved from association to …

Phylum Gemmatimonadota and its role in the environment

I Mujakić, K Piwosz, M Koblížek - Microorganisms, 2022 - mdpi.com
Bacteria are an important part of every ecosystem that they inhabit on Earth. Environmental
microbiologists usually focus on a few dominant bacterial groups, neglecting less abundant …

Extending and improving metagenomic taxonomic profiling with uncharacterized species using MetaPhlAn 4

A Blanco-Míguez, F Beghini, F Cumbo, LJ McIver… - Nature …, 2023 - nature.com
Metagenomic assembly enables new organism discovery from microbial communities, but it
can only capture few abundant organisms from most metagenomes. Here we present …

GTDB-Tk v2: memory friendly classification with the genome taxonomy database

PA Chaumeil, AJ Mussig, P Hugenholtz… - …, 2022 - academic.oup.com
Abstract Summary The Genome Taxonomy Database (GTDB) and associated taxonomic
classification toolkit (GTDB-Tk) have been widely adopted by the microbiology community …

Identification of mobile genetic elements with geNomad

AP Camargo, S Roux, F Schulz, M Babinski, Y Xu… - Nature …, 2023 - nature.com
Identifying and characterizing mobile genetic elements in sequencing data is essential for
understanding their diversity, ecology, biotechnological applications and impact on public …

Interactive Tree of Life (iTOL) v6: recent updates to the phylogenetic tree display and annotation tool

I Letunic, P Bork - Nucleic Acids Research, 2024 - academic.oup.com
Abstract The Interactive Tree Of Life (https://itol. embl. de) is an online tool for the
management, display, annotation and manipulation of phylogenetic and other trees. It is …

Greengenes2 unifies microbial data in a single reference tree

D McDonald, Y Jiang, M Balaban, K Cantrell… - Nature …, 2024 - nature.com
Studies using 16S rRNA and shotgun metagenomics typically yield different results, usually
attributed to PCR amplification biases. We introduce Greengenes2, a reference tree that …

IMG/VR v4: an expanded database of uncultivated virus genomes within a framework of extensive functional, taxonomic, and ecological metadata

AP Camargo, S Nayfach, IMA Chen… - Nucleic acids …, 2023 - academic.oup.com
Viruses are widely recognized as critical members of all microbiomes. Metagenomics
enables large-scale exploration of the global virosphere, progressively revealing the …

iPHoP: An integrated machine learning framework to maximize host prediction for metagenome-derived viruses of archaea and bacteria

S Roux, AP Camargo, FH Coutinho, SM Dabdoub… - PLoS …, 2023 - journals.plos.org
The extraordinary diversity of viruses infecting bacteria and archaea is now primarily studied
through metagenomics. While metagenomes enable high-throughput exploration of the viral …

Ensembl Genomes 2022: an expanding genome resource for non-vertebrates

AD Yates, J Allen, RM Amode, AG Azov… - Nucleic acids …, 2022 - academic.oup.com
Abstract Ensembl Genomes (https://www. ensemblgenomes. org) provides access to non-
vertebrate genomes and analysis complementing vertebrate resources developed by the …