Neuraxial cytokines in pain states

G Gonçalves dos Santos, L Delay, TL Yaksh… - Frontiers in …, 2020 - frontiersin.org
A high-intensity potentially tissue-injuring stimulus generates a homotopic response to
escape the stimulus and is associated with an affective phenotype considered to represent …

Crosstalk between vascular endothelial growth factor, notch, and transforming growth factor-β in vascular morphogenesis

MT Holderfield, CCW Hughes - Circulation research, 2008 - Am Heart Assoc
Vascular morphogenesis encompasses a temporally regulated set of morphological
changes that endothelial cells undergo to generate a network of interconnected tubules …

Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice

M Nishio, K Sugimachi, H Goto… - Proceedings of the …, 2016 - National Acad Sciences
Mps One Binder Kinase Activator (MOB) 1A/1B are core components of the Hippo pathway
that coactivate large tumor suppressor homolog (LATS) kinases. Mob1a/1b double …

Insulin signaling and the regulation of insect diapause

C Sim, DL Denlinger - Frontiers in physiology, 2013 - frontiersin.org
A rich chapter in the history of insect endocrinology has focused on hormonal control of
diapause, especially the major roles played by juvenile hormones (JHs), ecdysteroids, and …

[HTML][HTML] Spectrins: a structural platform for stabilization and activation of membrane channels, receptors and transporters

B Machnicka, A Czogalla… - … et Biophysica Acta (BBA …, 2014 - Elsevier
This review focuses on structure and functions of spectrin as a major component of the
membrane skeleton. Recent advances on spectrin function as an interface for signal …

Mechanisms and pathways of growth failure in primordial dwarfism

A Klingseisen, AP Jackson - Genes & development, 2011 - genesdev.cshlp.org
The greatest difference between species is size; however, the developmental mechanisms
determining organism growth remain poorly understood. Primordial dwarfism is a group of …

Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2α) dephosphorylation in mammalian development

HP Harding, Y Zhang, D Scheuner… - Proceedings of the …, 2009 - National Acad Sciences
Diverse cellular stress responses are linked to phosphorylation of serine 51 on the alpha
subunit of translation initiation factor 2. The resultant attenuation of protein synthesis and …

TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine

A Maheshwari, DR Kelly, T Nicola, N Ambalavanan… - Gastroenterology, 2011 - Elsevier
BACKGROUND & AIMS: Premature neonates are predisposed to necrotizing enterocolitis
(NEC), an idiopathic, inflammatory bowel necrosis. We investigated whether NEC occurs in …

Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva

A Chaikuad, I Alfano, G Kerr, CE Sanvitale… - Journal of Biological …, 2012 - ASBMB
Bone morphogenetic protein (BMP) receptor kinases are tightly regulated to control
development and tissue homeostasis. Mutant receptor kinase domains escape regulation …

Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells

J Hao, MA Daleo, CK Murphy, PB Yu, JN Ho, J Hu… - PloS one, 2008 - journals.plos.org
Background Pluripotent embryonic stem (ES) cells, which have the capacity to give rise to all
tissue types in the body, show great promise as a versatile source of cells for regenerative …