Mortality-related risk factors of COVID-19: a systematic review and meta-analysis of 42 studies and 423,117 patients

ZG Dessie, T Zewotir - BMC infectious diseases, 2021 - Springer
Background Mortality rates of coronavirus disease-2019 (COVID-19) continue to rise across
the world. The impact of several risk factors on coronavirus mortality has been previously …

Sex differences in immunity to viral infections

H Jacobsen, SL Klein - Frontiers in immunology, 2021 - frontiersin.org
The ongoing COVID-19 pandemic has increased awareness about sex-specific differences
in immunity and outcomes following SARS-CoV-2 infection. Strong evidence of a male bias …

Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission

H Peckham, NM de Gruijter, C Raine… - Nature …, 2020 - nature.com
Anecdotal evidence suggests that Coronavirus disease 2019 (COVID-19), caused by the
coronavirus SARS-CoV-2, exhibits differences in morbidity and mortality between sexes …

Sex hormone signaling and regulation of immune function

JP Hoffmann, JA Liu, K Seddu, SL Klein - Immunity, 2023 - cell.com
Immune responses to antigens, including innocuous, self, tumor, microbial, and vaccine
antigens, differ between males and females. The quest to uncover the mechanisms for …

Sexual-dimorphism in human immune system aging

EJ Márquez, C Chung, R Marches, RJ Rossi… - Nature …, 2020 - nature.com
Differences in immune function and responses contribute to health-and life-span disparities
between sexes. However, the role of sex in immune system aging is not well understood …

Effects of sex and aging on the immune cell landscape as assessed by single-cell transcriptomic analysis

Z Huang, B Chen, X Liu, H Li, L Xie… - Proceedings of the …, 2021 - National Acad Sciences
Sex and aging influence the human immune system, resulting in disparate responses to
infection, autoimmunity, and cancer. However, the impact of sex and aging on the immune …

Cancer immunotherapy efficacy and patients' sex: a systematic review and meta-analysis

F Conforti, L Pala, V Bagnardi, T De Pas… - The Lancet …, 2018 - thelancet.com
Background Despite the acknowledged sex-related dimorphism in immune system
response, little is known about the effect of patients' sex on the efficacy of immune …

[HTML][HTML] Sex differences in immune responses

SL Klein, KL Flanagan - Nature Reviews Immunology, 2016 - nature.com
Males and females differ in their immunological responses to foreign and self-antigens and
show distinctions in innate and adaptive immune responses. Certain immunological sex …

Sex differences in cancer mechanisms

JB Rubin, JS Lagas, L Broestl, J Sponagel… - Biology of sex …, 2020 - Springer
We now know that cancer is many different diseases, with great variation even within a
single histological subtype. With the current emphasis on developing personalized …

Sex and gender differences in bacterial infections

SP Dias, MC Brouwer, D van de Beek - Infection and Immunity, 2022 - Am Soc Microbiol
There is a growing awareness of the importance of sex and gender in medicine and
research. Women typically have stronger immune responses to self and foreign antigens …