The molecular mechanisms underlying anti‐inflammatory effects of galangin in different diseases

EHM Hassanein, MS Abd El‐Maksoud… - Phytotherapy …, 2023 - Wiley Online Library
When used as an alternative source of drugs to treat inflammation‐associated diseases,
phytochemicals with anti‐inflammatory properties provide beneficial impacts. Galangin is …

Mechanisms underlying dose-limiting toxicities of conventional chemotherapeutic agents

MA Manavi, MH Fathian Nasab… - Journal of …, 2023 - Taylor & Francis
Dose-limiting toxicities (DLTs) are severe adverse effects that define the maximum tolerated
dose of a cancer drug. In addition to the specific mechanisms of each drug, common …

Methotrexate-induced liver injury is associated with oxidative stress, impaired mitochondrial respiration, and endoplasmic reticulum stress in vitro

S Schmidt, CJ Messner, C Gaiser, C Hämmerli… - International journal of …, 2022 - mdpi.com
Low-dose methotrexate (MTX) is a standard therapy for rheumatoid arthritis due to its low
cost and efficacy. Despite these benefits, MTX has been reported to cause chronic drug …

Acetovanillone augmented the cardioprotective effect of carvedilol against cadmium-induced heart injury via suppression of oxidative stress and inflammation …

EHM Hassanein, AG Bakr, EAM El-Shoura… - Scientific reports, 2023 - nature.com
Cardiac toxicity is a public health issue that can be caused by both environmental and
occupational exposures. The current study aimed to investigate the effectiveness of …

Buspirone attenuated methotrexate‐induced hippocampal toxicity in rats by regulating Nrf2/HO‐1, PPAR‐γ, NF‐κB/nNOS, and ROS/NLRP3/caspase‐1 signaling …

HS Althagafy, ZW Sharawi, AH Batawi… - … of Biochemical and …, 2023 - Wiley Online Library
Methotrexate (MTX) is a chemotherapeutic agent widely used to treat a variety of tumors.
Nonetheless, MTX‐induced hippocampal neurotoxicity is a well‐defined dose‐limiting …

The hepatoprotective potential of tannic acid against doxorubicin‐induced hepatotoxicity: Insights into its antioxidative, anti‐inflammatory, and antiapoptotic …

N Özturk, H Ceylan, Y Demir - Journal of Biochemical and …, 2024 - Wiley Online Library
Doxorubicin (DOX), which is frequently used in cancer treatment, has limited clinical use due
to adverse effects on healthy tissues, especially the liver. Therefore, it is necessary to …

Spirulina and thymoquinone protect against methotrexate-induced hepatic injury in rats

A Behairy, A Elkomy, F Elsayed, MMS Gaballa… - Revista Brasileira de …, 2024 - Springer
Methotrexate is a chemotherapy medication frequently used to treat various forms of cancer.
The purpose of this research was to examine if the administration of Arthrospira platensis …

Vinpocetine mitigates methotrexate-induced duodenal intoxication by modulating NF-κB, JAK1/STAT-3, and RIPK1/RIPK3/MLKL signals

HM Tashkandi, HS Althagafy, FA Jaber… - …, 2024 - Taylor & Francis
Objectives Methotrexate (MTX) is an antimetabolite agent widely used to manage a variety
of tumors and autoimmune diseases. Nonetheless, MTX-induced intestinal intoxication is a …

Umbelliferone potentiates intestinal protective effect of Lactobacillus Acidophilus against methotrexate-induced intestinal injury: Biochemical and histological study

EHM Hassanein, FEM Ali, MM Sayed, AR Mahmoud… - Tissue and Cell, 2023 - Elsevier
Intestinal injury is a common adverse effect of methotrexate (MTX) therapy, limiting its
clinical use. Despite oxidative stress and inflammation being the most embedded …

Fasudil ameliorates methotrexate-induced hepatotoxicity by modulation of redox-sensitive signals

EM Aboubakr, ARN Ibrahim, FEM Ali, AAE Mourad… - Pharmaceuticals, 2022 - mdpi.com
Methotrexate (MTX) is one of the most widely used cytotoxic chemotherapeutic agents, and it
is used in the treatment of different autoimmune disorders. However, the clinical applications …