The molecular mechanisms underlying anti‐inflammatory effects of galangin in different diseases
EHM Hassanein, MS Abd El‐Maksoud… - Phytotherapy …, 2023 - Wiley Online Library
When used as an alternative source of drugs to treat inflammation‐associated diseases,
phytochemicals with anti‐inflammatory properties provide beneficial impacts. Galangin is …
phytochemicals with anti‐inflammatory properties provide beneficial impacts. Galangin is …
Mechanisms underlying dose-limiting toxicities of conventional chemotherapeutic agents
MA Manavi, MH Fathian Nasab… - Journal of …, 2023 - Taylor & Francis
Dose-limiting toxicities (DLTs) are severe adverse effects that define the maximum tolerated
dose of a cancer drug. In addition to the specific mechanisms of each drug, common …
dose of a cancer drug. In addition to the specific mechanisms of each drug, common …
Methotrexate-induced liver injury is associated with oxidative stress, impaired mitochondrial respiration, and endoplasmic reticulum stress in vitro
S Schmidt, CJ Messner, C Gaiser, C Hämmerli… - International journal of …, 2022 - mdpi.com
Low-dose methotrexate (MTX) is a standard therapy for rheumatoid arthritis due to its low
cost and efficacy. Despite these benefits, MTX has been reported to cause chronic drug …
cost and efficacy. Despite these benefits, MTX has been reported to cause chronic drug …
Acetovanillone augmented the cardioprotective effect of carvedilol against cadmium-induced heart injury via suppression of oxidative stress and inflammation …
EHM Hassanein, AG Bakr, EAM El-Shoura… - Scientific reports, 2023 - nature.com
Cardiac toxicity is a public health issue that can be caused by both environmental and
occupational exposures. The current study aimed to investigate the effectiveness of …
occupational exposures. The current study aimed to investigate the effectiveness of …
Buspirone attenuated methotrexate‐induced hippocampal toxicity in rats by regulating Nrf2/HO‐1, PPAR‐γ, NF‐κB/nNOS, and ROS/NLRP3/caspase‐1 signaling …
HS Althagafy, ZW Sharawi, AH Batawi… - … of Biochemical and …, 2023 - Wiley Online Library
Methotrexate (MTX) is a chemotherapeutic agent widely used to treat a variety of tumors.
Nonetheless, MTX‐induced hippocampal neurotoxicity is a well‐defined dose‐limiting …
Nonetheless, MTX‐induced hippocampal neurotoxicity is a well‐defined dose‐limiting …
The hepatoprotective potential of tannic acid against doxorubicin‐induced hepatotoxicity: Insights into its antioxidative, anti‐inflammatory, and antiapoptotic …
Doxorubicin (DOX), which is frequently used in cancer treatment, has limited clinical use due
to adverse effects on healthy tissues, especially the liver. Therefore, it is necessary to …
to adverse effects on healthy tissues, especially the liver. Therefore, it is necessary to …
Spirulina and thymoquinone protect against methotrexate-induced hepatic injury in rats
A Behairy, A Elkomy, F Elsayed, MMS Gaballa… - Revista Brasileira de …, 2024 - Springer
Methotrexate is a chemotherapy medication frequently used to treat various forms of cancer.
The purpose of this research was to examine if the administration of Arthrospira platensis …
The purpose of this research was to examine if the administration of Arthrospira platensis …
Vinpocetine mitigates methotrexate-induced duodenal intoxication by modulating NF-κB, JAK1/STAT-3, and RIPK1/RIPK3/MLKL signals
HM Tashkandi, HS Althagafy, FA Jaber… - …, 2024 - Taylor & Francis
Objectives Methotrexate (MTX) is an antimetabolite agent widely used to manage a variety
of tumors and autoimmune diseases. Nonetheless, MTX-induced intestinal intoxication is a …
of tumors and autoimmune diseases. Nonetheless, MTX-induced intestinal intoxication is a …
Umbelliferone potentiates intestinal protective effect of Lactobacillus Acidophilus against methotrexate-induced intestinal injury: Biochemical and histological study
Intestinal injury is a common adverse effect of methotrexate (MTX) therapy, limiting its
clinical use. Despite oxidative stress and inflammation being the most embedded …
clinical use. Despite oxidative stress and inflammation being the most embedded …
Fasudil ameliorates methotrexate-induced hepatotoxicity by modulation of redox-sensitive signals
Methotrexate (MTX) is one of the most widely used cytotoxic chemotherapeutic agents, and it
is used in the treatment of different autoimmune disorders. However, the clinical applications …
is used in the treatment of different autoimmune disorders. However, the clinical applications …