COVID-19-related health outcomes in people with primary immunodeficiency: A systematic review

E Drzymalla, RF Green, M Knuth, MJ Khoury… - Clinical …, 2022 - Elsevier
A better understanding of COVID-19 in people with primary immunodeficiency (PI), rare
inherited defects in the immune system, is important for protecting this population, especially …

Impact of SARS-CoV-2 infection and COVID-19 on patients with inborn errors of immunity

SG Tangye, L Abel, S Al-Muhsen, A Aiuti… - Journal of Allergy and …, 2023 - Elsevier
Since the arrival of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in
December 2019, its characterization as a novel human pathogen, and the resulting …

COVID-19 and inborn errors of immunity

OM Delmonte, R Castagnoli, LD Notarangelo - Physiology, 2022 - journals.physiology.org
Inborn errors of immunity (IEI) are a heterogeneous group of disorders affecting immune
host defense and immunoregulation. Considering the predisposition to develop severe and …

SARS-CoV-2 T cell response in severe and fatal COVID-19 in primary antibody deficiency patients without specific humoral immunity

S Steiner, T Schwarz, VM Corman, L Gebert… - Frontiers in …, 2022 - frontiersin.org
Morbidity and mortality of COVID-19 is increased in patients with inborn errors of immunity
(IEI). Age and comorbidities and also impaired type I interferon immunity were identified as …

The impact of SARS-CoV-2 infection in patients with inborn errors of immunity: the experience of the Italian primary immunodeficiencies network (IPINet)

G Giardino, C Milito, V Lougaris, A Punziano… - Journal of Clinical …, 2022 - Springer
COVID-19 manifestations range from asymptomatic to life-threatening infections. The
outcome in different inborn errors of immunity (IEI) is still a matter of debate. In this …

SARS-CoV-2 infection and response to COVID-19 vaccination in patients with primary immunodeficiencies

R Paris - The Journal of Infectious Diseases, 2023 - academic.oup.com
Primary immunodeficiencies (PIDs) are heterogeneous, rare disorders that increase
susceptibility to infection and/or immune dysregulation. Individuals with certain PIDs are at …

COVID-19 relapse associated with SARS-CoV-2 evasion from CD4+ T-cell recognition in an agammaglobulinemia patient

R Morita, R Kubota-Koketsu, X Lu, T Sasaki… - Iscience, 2023 - cell.com
A 25-year-old patient with a primary immunodeficiency lacking immunoglobulin production
experienced a relapse after a 239-day period of persistent severe acute respiratory …

Remdesivir decreases mortality in COVID-19 patients with active malignancy

J Jaroszewicz, J Kowalska, M Pawłowska, M Rogalska… - Cancers, 2022 - mdpi.com
Simple Summary Patients with active malignancies have an increased risk for severe SARS-
CoV-2 infection and high mortality from COVID-19. Additionally, due to the underlying …

Real-life data on monoclonal antibodies and antiviral drugs in Italian inborn errors of immunity patients during COVID-19 pandemic

G Garzi, F Cinetto, D Firinu, G Di Napoli… - Frontiers in …, 2022 - frontiersin.org
Background Since the beginning of the COVID-19 pandemic, patients with Inborn Errors of
Immunity have been infected by SARS-CoV-2 virus showing a spectrum of disease ranging …

Compassionate Use of REGEN-COV® in Patients With Coronavirus Disease 2019 (COVID-19) and Immunodeficiency-Associated Antibody Disorders

D Stein, E Oviedo-Orta, WA Kampman… - Clinical Infectious …, 2022 - academic.oup.com
Background Patients with immunodeficiency-associated antibody disorders are at a higher
risk of prolonged/persistent COVID-19 infection, having no viable treatment options …