Importance Heart failure with preserved ejection fraction (HFpEF), defined as HF with an EF
of 50% or higher at diagnosis, affects approximately 3 million people in the US and up to 32 …

Aims An algorithm for non‐invasive diagnosis of amyloid transthyretin cardiac amyloidosis
(ATTR‐CA) and novel disease‐modifying therapies have prompted an active search for CA …

Background Transthyretin amyloid (ATTR) cardiomyopathy is a progressive and fatal
disease caused by misfolded transthyretin. Despite advances in slowing disease …

The systemic amyloidoses are a broad spectrum of diseases that result from misfolding of
proteins that aggregate into b-sheet amyloid fibrils. Over 35 amyloidogenic precursor …

Patients with heart failure with preserved ejection fraction (HFpEF) universally complain of
exercise intolerance and dyspnoea as key clinical correlates. Cardiac as well as …

Aims To perform evaluation of widely embraced bone scintigraphy-based non-biopsy
diagnostic criteria (NBDC) for ATTR amyloid cardiomyopathy (ATTR-CM) in clinical practice …

Importance Transthyretin amyloid cardiomyopathy (ATTR-CM) is a form of heart failure (HF)
with preserved ejection fraction (HFpEF). Technetium Tc 99m pyrophosphate scintigraphy …

Importance Tafamidis has been shown to improve survival in patients with transthyretin
amyloid cardiomyopathy (ATTR-CM) compared with placebo. However, its effect on cardiac …

Aims The HFA‐PEFF and H2FPEF scores have been developed to diagnose heart failure
with preserved ejection fraction (HFpEF), and hold prognostic value. Their value in patients …

Importance Systemic amyloidosis from transthyretin (ATTR) protein is the most common type
of amyloidosis that causes cardiomyopathy. Observations Transthyretin (TTR) protein …