Melanoma progression is typically depicted as a linear and stepwise process in which
metastasis occurs relatively late in disease progression. Significant evidence suggests that …

Mutations in components of the Wnt pathways are a frequent cause of many human
diseases, particularly cancer. Despite the fact that a causative link between aberrant Wnt …

About half of all melanomas harbor a mutation that results in a constitutively active BRAF
kinase mutant (BRAFV600E/K) that can be selectively inhibited by targeted BRAF inhibitors …

Wnts are secreted palmitoylated glycoproteins that are important in embryonic development
and human cancers. Here we report a method for imaging the palmitoylated form of Wnt …

SOX2 is a key regulator of multiple types of stem cells, especially embryonic stem cells
(ESCs) and neural progenitor cells (NPCs). Understanding the mechanism underlying the …

In the three decades since the discovery of the Wnt1 proto-oncogene in virus-induced
mouse mammary tumours, our understanding of the signalling pathways that are regulated …

G protein-coupled receptors (GPCRs) are a large superfamily of cell-surface signaling
proteins that bind extracellular ligands and transduce signals into cells via heterotrimeric G …

Active regulation of protein abundance is an essential strategy to modulate cellular signaling
pathways. Within the Wnt signaling cascade, regulated degradation of β‐catenin by the …

Abstract β-catenin is required for establishment of leukemic stem cells (LSCs) in acute
myeloid leukemia (AML). Targeted inhibition of β-catenin signaling has been hampered by …

MicroRNAs (miRNAs) have emerged as critical regulators for malignant melanoma
development. miR-485-5p has been suggested as a tumor-suppressive miRNA in many …