The majority of infectious hepatitis C particles are present in the low-density fractions from
plasma of infected patients, suggesting an association of the virus with lipoproteins and the …

An estimated 170 million persons are infected with the hepatitis C virus (HCV) worldwide.
While hepatocytes are the major site of infection, a broad clinical spectrum of extrahepatic …

Patients with chronic hepatitis C virus (HCV) infection frequently report fatigue, lassitude,
depression, and a perceived inability to function effectively. Several studies have shown that …

Hepatitis C virus (HCV) envelope glycoproteins E1/E2 can pseudotype retroviral particles
and efficiently mediate entry into target cells. Using this experimental system, we determined …

It is unclear whether the current antiviral treatment for chronic hepatitis C virus (HCV)
infection results in complete elimination of the virus, or whether small quantities of virus …

Patients with chronic hepatitis C are more likely to have significant changes in their physical
and mental well-being than patients with liver disease of other etiology, and hepatitis C virus …

Reports of cerebral dysfunction in chronic hepatitis C virus (HCV) infection have led to the
suggestion that HCV may infect the central nervous system (CNS). We used reverse …

Target cell tropism of enveloped viruses is regulated by interactions between viral and
cellular factors during transmission, dissemination, and replication within the host. Binding of …

Hepatitis C virus (HCV) infection often is associated with cognitive dysfunction and
depression. HCV sequences and replicative forms were detected in autopsy brain tissue …

Hepatitis C virus (HCV) is a major cause of chronic hepatitis, liver cirrhosis, and
hepatocellular carcinoma. Studies of HCV replication and pathogenesis have so far been …