Biomolecular condensates are found throughout eukaryotic cells, including in the nucleus, in
the cytoplasm and on membranes. They are also implicated in a wide range of cellular …

Proteins undergoing liquid–liquid phase separation are being discovered at an increasing
rate. Since at the high concentrations present in the cell most proteins would be expected to …

Centrosomes catalyse the formation of microtubules needed to assemble the mitotic spindle
apparatus. Centrosomes themselves duplicate once per cell cycle, in a process that is …

Liquid–liquid phase separation (LLPS) is emerging as a mechanism of spatiotemporal
regulation that could answer long-standing questions about how order is achieved in …

The human kinome comprises 538 kinases playing essential functions by catalyzing protein
phosphorylation. Annotation of subcellular distribution of the kinome greatly facilitates …

Anaplastic lymphoma kinase (ALK) can be driven to oncogenic activity by different types of
mutational events such as point‐mutations, for example F1174L in neuroblastoma, and …

Variants of the oncogenic EML4‐ALK fusion protein contain a similar region of ALK
encompassing the kinase domain, but different portions of EML4. Here, we show that EML4 …

Polo-like kinases (Plks) are critical regulatory molecules during the cell cycle process. This
family has five members: Plk1, 2, 3, 4, and 5. Plk4 has been identified as a master regulator …

Centriole duplication is a high-fidelity process driven by Polo-like kinase 4 (Plk4) and a few
conserved initiators. Dissecting how Plk4 and its receptors organize within centrosomes is …

HIV-1 infection elevates the risk of developing various cancers, including T-cell lymphoma.
Whether HIV-1-encoded proteins directly contribute to oncogenesis remains unknown. We …