Macrophages are crucial members of the innate immune response and important regulators.
The differentiation and activation of macrophages require the timely regulation of gene …

Lipopolysaccharide (LPS) from Gram-negative bacteria is one of the most potent innate
immune-activating stimuli known. Here we review the current understanding of LPS effects …

Aims: The response of AMP-activated protein kinase (AMPK) to oxidative stress has been
recently reported but the downstream signals of this response are largely unknown …

Histone deacetylases (HDACs) remove an acetyl group from lysine residues of target
proteins to regulate cellular processes. Small-molecule inhibitors of HDACs cause cellular …

Chronic inflammation plays a multifaceted role in carcinogenesis. Mounting evidence from
preclinical and clinical studies suggests that persistent inflammation functions as a driving …

The immune microenvironment plays a critical role in regulating skin wound healing.
Macrophages, the main component of infiltrating inflammatory cells, play a pivotal role in …

Highlights•This review is focusing on polarization of macrophages by epigenetic
modifications.•M1/M2 macrophages are flawlessly synchronized, specialized, and perform …

Regulated by histone acetyltransferases and deacetylases (HDACs), histone acetylation is a
key epigenetic mechanism controlling chromatin structure, DNA accessibility, and gene …

Background Selective serotonin reuptaker inhibitors, including fluoxetine, are widely studied
and prescribed antidepressants, while their exact molecular and cellular mechanism are yet …

Monocyte/macrophage polarization in skeletal muscle regeneration is ill defined. We used
CD11b-diphtheria toxin receptor transgenic mice to transiently deplete monocytes …