Reaching the last mile: main challenges relating to and recommendations to accelerate onchocerciasis elimination in Africa

G Gebrezgabiher, Z Mekonnen… - Infectious diseases of …, 2019 - mednexus.org
Background: Onchocerciasis (river blindness), caused by the filarial worm species
Onchocerca volvulus, is a serious vector-borne neglected tropical disease (NTD) of public …

[HTML][HTML] Research for new drugs for elimination of onchocerciasis in Africa

AC Kuesel - International Journal for Parasitology: Drugs and Drug …, 2016 - Elsevier
Onchocerciasis is a parasitic, vector borne disease caused by the filarial nematode
Onchocerca volvulus. More than 99% of the population at risk of infection live in Africa …

African Programme for Onchocerciasis Control 1995–2015: model-estimated health impact and cost

LE Coffeng, WA Stolk, HGM Zoure… - PLoS neglected …, 2013 - journals.plos.org
Background Onchocerciasis causes a considerable disease burden in Africa, mainly
through skin and eye disease. Since 1995, the African Programme for Onchocerciasis …

High prevalence of epilepsy in two rural onchocerciasis endemic villages in the Mahenge area, Tanzania, after 20 years of community directed treatment with …

BP Mmbando, P Suykerbuyk, M Mnacho… - Infectious diseases of …, 2018 - Springer
Background Epilepsy is a neurological disorder with a multitude of underlying causes, which
may include infection with Onchocerca volvulus, the parasitic worm that causes human …

River blindness: mathematical models for control and elimination

MG Basáñez, M Walker, HC Turner, LE Coffeng… - Advances in …, 2016 - Elsevier
Human onchocerciasis (river blindness) is one of the few neglected tropical diseases
(NTDs) whose control strategies have been informed by mathematical modelling. With the …

Persistence of onchocerciasis and associated dermatologic and ophthalmic pathologies after 27 years of ivermectin mass drug administration in the middle belt of …

KB Otabil, MG Basáñez, B Ankrah… - Tropical Medicine & …, 2023 - Wiley Online Library
Objectives There is a pressing need to regularly evaluate the progress of onchocerciasis
elimination programmes to timely identify and mitigate potential risks hindering the reaching …

Modelling the impact of ivermectin on River Blindness and its burden of morbidity and mortality in African Savannah: EpiOncho projections

HC Turner, M Walker, TS Churcher, MG Basáñez - Parasites & vectors, 2014 - Springer
Abstract Background The African Programme for Onchocerciasis Control (APOC) has
refocused its goals on the elimination of infection where possible, seemingly achievable by …

Community-driven interventions can revolutionise control of neglected tropical diseases

UV Amazigo, SGA Leak, HGM Zoure, N Njepuome… - Trends in …, 2012 - cell.com
Whether global health interventions target diseases (vertical), systems (horizontal) or both
(diagonal), they must address the challenge of delivering services in very remote areas of …

Why onchocerciasis transmission persists after 15 annual ivermectin mass drug administrations in South-West Cameroon

A Forrer, S Wanji, ED Obie, TM Nji, L Hamill… - BMJ global …, 2021 - gh.bmj.com
Introduction Onchocerciasis is targeted for elimination mainly with annual community-
directed treatment with ivermectin (CDTI). High infection levels have been reported in South …

Detection of Plasmodium falciparum in laboratory-reared and naturally infected wild mosquitoes using near-infrared spectroscopy

DF Da, R McCabe, BM Somé, PM Esperança… - Scientific Reports, 2021 - nature.com
There is an urgent need for high throughput, affordable methods of detecting pathogens
inside insect vectors to facilitate surveillance. Near-infrared spectroscopy (NIRS) has shown …