All intracellular proteins and many extracellular proteins are continually “turning over;” ie,
they are being hydrolyzed to their constituent amino acids and replaced by new synthesis …

Misfolded proteins compromise cellular homeostasis. This is especially problematic in the
endoplasmic reticulum (ER), which is a high-capacity protein-folding compartment and …

The epithelial Na+ channel (ENaC) is a tetramer of two α-, one β-, and one γ-subunit, but
little is known about its assembly and processing. Because co-expression of mouse ENaC …

The epithelial Na+ channel (ENaC) is a pathway for Na+ transport across epithelia,
including the kidney collecting duct, lung, and distal colon. ENaC is critical for Na+ …

The epithelial Na+ channel (ENaC), located in the apical membrane of renal aldosterone-
responsive epithelia, plays an essential role in controlling the Na+ balance of extracellular …

Abstract The epithelial Na+ channel (ENaC) forms the pathway for Na+ absorption in the
kidney collecting duct and other epithelia. Dominant gain-of-function mutations cause …

Fine regulation of water reabsorption by the antidiuretic hormone [8-arginine] vasopressin
(AVP) occurs in principal cells of the collecting duct and is largely dependent on regulation …

Acute hormonal regulation of the epithelial sodium channel (ENaC) in tight epithelia
increases transcellular Na+ transport via trafficking of intracellular channels to the apical …

The members of the cytoplasmic 70-kDa heat shock protein family are involved in
appropriate folding and trafficking of newly synthesized proteins in the cell. Hsc70, which is …

Phosphatidylinositol 4, 5-bisphosphate (PIP 2) is a membrane lipid found in all eukaryotic
cells, which regulates many important cellular processes, including ion channel activity. In …